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Literature DB >> 15302838

The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans.

Michael Kruppa¹, Bastiaan P Krom, Neeraj Chauhan, Adrienne V Bambach, Ronald L Cihlar, Richard A Calderone.

Abstract

Regulation of hyphal morphogenesis in Candida albicans can occur through quorum sensing (QS). A QS signal, farnesol, is produced during high-density growth and inhibits morphogenesis. However, the signal transduction pathway that regulates QS is unknown. Here, we show that a C. albicans mutant lacking Chk1p but not either the Sln1p or the Nik1p histidine kinase is refractory to the inhibitory effect of farnesol both in cell suspension and during the formation of a biofilm. This study is the first to demonstrate a role for a two-component signal transduction protein in QS by a eukaryotic organism.

Entities: Chemical Species

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Year: 2004 PMID： 15302838 PMCID： PMC500889 DOI： 10.1128/EC.3.4.1062-1065.2004

Source DB: PubMed Journal: Eukaryot Cell ISSN： 1535-9786

19 in total

1. Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism.

Authors: Sanghee Kim; Eunkyung Kim; Dong Sun Shin; Heonjoong Kang; Ki Bong Oh
Journal: Bioorg Med Chem Lett Date: 2002-03-25 Impact factor: 2.823

Review 2. Quorum sensing in bacteria.

Authors: M B Miller; B L Bassler
Journal: Annu Rev Microbiol Date: 2001 Impact factor: 15.500

3. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule.

Authors: Gordon Ramage; Stephen P Saville; Brian L Wickes; José L López-Ribot
Journal: Appl Environ Microbiol Date: 2002-11 Impact factor: 4.792

4. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans.

Authors: T Yamada-Okabe; T Mio; N Ono; Y Kashima; M Matsui; M Arisawa; H Yamada-Okabe
Journal: J Bacteriol Date: 1999-12 Impact factor: 3.490

5. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.

Authors: J M Hornby; E C Jensen; A D Lisec; J J Tasto; B Jahnke; R Shoemaker; P Dussault; K W Nickerson
Journal: Appl Environ Microbiol Date: 2001-07 Impact factor: 4.792

Review 6. Osmotic stress signaling and osmoadaptation in yeasts.

Authors: Stefan Hohmann
Journal: Microbiol Mol Biol Rev Date: 2002-06 Impact factor: 11.056

7. Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans.

Authors: J A Calera; R Calderone
Journal: Microbiology Date: 1999-06 Impact factor: 2.777

Review 8. Candida biofilms and their role in infection.

Authors: L Julia Douglas
Journal: Trends Microbiol Date: 2003-01 Impact factor: 17.079

9. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs.

Authors: Roman Shchepin; Jacob M Hornby; Erin Burger; Timothy Niessen; Patrick Dussault; Kenneth W Nickerson
Journal: Chem Biol Date: 2003-08

10. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Authors: V Buck; J Quinn; T Soto Pino; H Martin; J Saldanha; K Makino; B A Morgan; J B Millar
Journal: Mol Biol Cell Date: 2001-02 Impact factor: 4.138

49 in total

Review 1. Candida albicans Biofilms and Human Disease.

Authors: Clarissa J Nobile; Alexander D Johnson
Journal: Annu Rev Microbiol Date: 2015 Impact factor: 15.500

2. Genetic control of Candida albicans biofilm development.

Authors: Jonathan S Finkel; Aaron P Mitchell
Journal: Nat Rev Microbiol Date: 2010-12-29 Impact factor: 60.633

Review 3. Candida biofilms: an update.

Authors: Gordon Ramage; Stephen P Saville; Derek P Thomas; José L López-Ribot
Journal: Eukaryot Cell Date: 2005-04

The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans.

1. Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism.

Review 2. Quorum sensing in bacteria.

3. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule.

4. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans.

5. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.

Review 6. Osmotic stress signaling and osmoadaptation in yeasts.

7. Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans.

Review 8. Candida biofilms and their role in infection.

9. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs.

10. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Review 1. Candida albicans Biofilms and Human Disease.

2. Genetic control of Candida albicans biofilm development.

Review 3. Candida biofilms: an update.

Review 4. Talking to themselves: autoregulation and quorum sensing in fungi.

Review 5. Quorum sensing in dimorphic fungi: farnesol and beyond.

6. 8th ASM conference on Candida and candidiasis: molecular tools provide insights into host-pathogen interactions.

Review 7. Two-component signal transduction proteins as potential drug targets in medically important fungi.

8. The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan.

9. Presence of extracellular DNA in the Candida albicans biofilm matrix and its contribution to biofilms.

10. Mitochondrial two-component signaling systems in Candida albicans.