Literature DB >> 16085901

Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.

Daniel D Mosel1, Raluca Dumitru, Jacob M Hornby, Audrey L Atkin, Kenneth W Nickerson.   

Abstract

Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 microM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 microM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

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Year:  2005        PMID: 16085901      PMCID: PMC1183276          DOI: 10.1128/AEM.71.8.4938-4940.2005

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN: 0099-2240            Impact factor:   4.792


  14 in total

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