Literature DB >> 1194858

Activated macrophages release a factor which lyses malignant cells but not normal cells.

G A Currie, C Basham.   

Abstract

When rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. Although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. This tumor-selective lytic effect is mediated by a labile supernatant product.

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Year:  1975        PMID： 1194858      PMCID： PMC2190066          DOI： 10.1084/jem.142.6.1600

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  The in vitro killing of syngeneic cells by peritoneal cells from adjuvant-stimulated mice.

Authors:  J T Jones; W H McBride; D M Weir
Journal:  Cell Immunol       Date:  1975-08       Impact factor: 4.868

2.  Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages.

Authors:  H G Opitz; D Niethammer; H Lemke; H D Flad; R Huget
Journal:  Cell Immunol       Date:  1975-04       Impact factor: 4.868

3.  Macrophages activated in vitro with lymphocyte mediators kill neoplastic but not normal cells.

Authors:  W F Piessens; W H Churchill
Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422

4.  Cytotoxicity in vitro by products of specifically stimulated spleen cells: susceptibility of tumor cells and normal cells.

Authors:  M S Meltzer; G L Bartlett
Journal:  J Natl Cancer Inst       Date:  1972-11       Impact factor: 13.506

5.  Macrophage nonimmunologic recognition: target cell factors related to contact inhibition.

Authors:  J B Hibbs
Journal:  Science       Date:  1973-05-25       Impact factor: 47.728

6.  Interaction of BCG-activated macrophages with neoplastic and nonneoplastic cell lines in vitro : quantitation of the cytotoxic reaction by release of tritiated thymidine from prelabeled target cells.

Authors:  M S Meltzer; R W Tucker; K K Sanford; E J Leonard
Journal:  J Natl Cancer Inst       Date:  1975-05       Impact factor: 13.506

7.  Acquired cellular immunity: extracellular killing of Listeria monocytogenes by a product of immunologically activated macrophages.

Authors:  R C Bast; R P Cleveland; B H Littman; B Zbar; H J Rapp
Journal:  Cell Immunol       Date:  1974-02       Impact factor: 4.868

8.  Macrophage-mediated cytotoxicity: its possible role in rheumatoid arthritis.

Authors:  R Evans
Journal:  Ann N Y Acad Sci       Date:  1975-06-13       Impact factor: 5.691

9.  Evidence for a cytolytic factor released by macrophages.

Authors:  H Melsom; G Kearny; S Gruca; R Seljelid
Journal:  J Exp Med       Date:  1974-10-01       Impact factor: 14.307

10.  Growth of normal and transformed rat embryo fibroblasts: effects of glycolipids from Salmonella minnesota R mutants.

Authors:  C Brailovsky; M Trudel; R Lallier; V N Nigam
Journal:  J Cell Biol       Date:  1973-04       Impact factor: 10.539
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  37 in total

Review 1.  Secretory function of mononuclear phagocytes: a review.

Authors:  E R Unanue
Journal:  Am J Pathol       Date:  1976-05       Impact factor: 4.307

2.  Macrophage infiltration of breast tumours: a prospective study.

Authors:  I Lauder; W Aherne; J Stewart; R Sainsbury
Journal:  J Clin Pathol       Date:  1977-06       Impact factor: 3.411

Review 3.  The effects of bacterial endotoxins on host mediation systems. A review.

Authors:  D C Morrison; R J Ulevitch
Journal:  Am J Pathol       Date:  1978-11       Impact factor: 4.307

4.  Suppression of both macrophage-mediated tumor cell lysis and cytolytic factor production by a factor (CIF) derived from normal embryonic fibroblasts.

Authors:  R Gallily; G E Gifford; J Loewenstein
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

5.  Modulation of hepatocyte protein synthesis by endotoxin-activated Kupffer cells. III. Evidence for the role of a monokine similar to but not identical with interleukin-1.

Authors:  G A Keller; M A West; J T Harty; L A Wilkes; F B Cerra; R L Simmons
Journal:  Ann Surg       Date:  1985-04       Impact factor: 12.969

6.  Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

Authors:  D Pennica; J S Hayflick; T S Bringman; M A Palladino; D V Goeddel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

7.  Antitumor effects of bacterial lipopolysaccharide and tumor necrosis factor in mice.

Authors:  N Moriya; H Miwa; K Orita
Journal:  Jpn J Surg       Date:  1984-03

8.  Ultrastructural studies of the interaction between liposome-activated human blood monocytes and allogeneic tumor cells in vitro.

Authors:  C D Bucana; L C Hoyer; A J Schroit; E Kleinerman; I J Fidler
Journal:  Am J Pathol       Date:  1983-07       Impact factor: 4.307

9.  Immunological studies on drug-induced allergic hepatitis--hepatocellular injury by macrophage-mediated cytotoxicity.

Authors:  Y Mizoguchi; T Shiba; F Ohnishi; T Monna; S Yamamoto; S Otani; S Morisawa
Journal:  Gastroenterol Jpn       Date:  1980

10.  Serum inhibitory effect on myeloperoxidase in human cancer.

Authors:  B Senelar; R Michel; J Tournamille; H Vannereau; M J Escola; J Taib; A Craste de Paulet
Journal:  Br J Exp Pathol       Date:  1982-06
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