Literature DB >> 4427087

Evidence for a cytolytic factor released by macrophages.

H Melsom, G Kearny, S Gruca, R Seljelid.   

Abstract

Mouse peritoneal macrophages cultivated in vitro acquire a strong extracellular cytotoxic activity towards isotope labeled syngeneic erythrocytes as demonstrated by isotope release to the medium. This lytic process is mediated by an extremely labile macrophage cytolytic factor (MCF) which is not detected under ordinary tissue culture conditions with serum present in the medium. By the use of serum-free medium containing low doses of 2-mercaptoethanol MCF is stabilized and found to be an easily dialysable, low molecular substance which resists heating at 60 degrees C for 30 min.

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Year:  1974        PMID： 4427087      PMCID： PMC2139636          DOI： 10.1084/jem.140.4.1085

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  14 in total

1.  Enhancement by reducing agents of the transformation of human and rabbit peripheral lymphocytes.

Authors:  M W Fanger; D A Hart; J V Wells; A Nisonoff
Journal:  J Immunol       Date:  1970-10       Impact factor: 5.422

2.  Cytotoxic factor from peritoneal cells: purification and characteristics.

Authors:  D E Sintek; W B Pincus
Journal:  J Reticuloendothel Soc       Date:  1970-12

3.  Ultrastructural visualization of cellular carbohydrate components by means of concanavalin A.

Authors:  W Bernhard; S Avrameas
Journal:  Exp Cell Res       Date:  1971-01       Impact factor: 3.905

4.  The in vitro induction and release of a cell toxin by immune C57B1-6 mouse peritoneal macrophages.

Authors:  J J Kramer; G A Granger
Journal:  Cell Immunol       Date:  1972-01       Impact factor: 4.868

5.  Lymphocyte-activating factors released in vitro by sensitized and nonsensitized human lymphocytes.

Authors:  R E Falk; J A Falk; E Möller; G Möller
Journal:  Cell Immunol       Date:  1970-07       Impact factor: 4.868

6.  Cytotoxic interaction of phytohemagglutinin-stimulated blood lymphocytes with monolayer cells: a study by light and electron microscopy.

Authors:  P Biberfeld
Journal:  Cell Immunol       Date:  1971-02       Impact factor: 4.868

7.  Fine structures of capillary and endocapillary layer as revealed by ruthenium red.

Authors:  J H Luft
Journal:  Fed Proc       Date:  1966 Nov-Dec

8.  The effects of mercaptoethanol and of peritoneal macrophages on the antibody-forming capacity of nonadherent mouse spleen cells in vitro.

Authors:  C Chen; J G Hirsch
Journal:  J Exp Med       Date:  1972-09-01       Impact factor: 14.307

9.  Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man.

Authors:  A F LoBuglio; R S Cotran; J H Jandl
Journal:  Science       Date:  1967-12-22       Impact factor: 47.728

10.  The cytotoxic effect of mouse macrophages on syngeneic and allogeneic erythrocytes.

Authors:  H Melsom; R Seljelid
Journal:  J Exp Med       Date:  1973-03-01       Impact factor: 14.307
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  9 in total

Review 1.  Secretory function of mononuclear phagocytes: a review.

Authors:  E R Unanue
Journal:  Am J Pathol       Date:  1976-05       Impact factor: 4.307

2.  Further observations on the process of haemophagocytosis in the human outflow system.

Authors:  I Grierson; W R Lee
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1978-11-08

3.  Some cellular aspects of chronic inflammation in joint disease.

Authors:  G Loewi; J Reynolds
Journal:  Agents Actions       Date:  1976-02

4.  Multiple systems organ failure. Modulation of hepatocyte protein synthesis by endotoxin activated Kupffer cells.

Authors:  G A Keller; M A West; F B Cerra; R L Simmons
Journal:  Ann Surg       Date:  1985-01       Impact factor: 12.969

5.  Enhancement of peritoneal macrophage activity by bovine gamma globulin in mice.

Authors:  P Di Nardo; G De Sanctis; P De Sole; L Carosella; S Lippa; F Piemonte; C Giordano; A Falera; P Massari; P Orlando
Journal:  Experientia       Date:  1986-12-01

6.  Activated macrophages release a factor which lyses malignant cells but not normal cells.

Authors:  G A Currie; C Basham
Journal:  J Exp Med       Date:  1975-12-01       Impact factor: 14.307

7.  Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

Authors:  C F Nathan; S C Silverstein; L H Brukner; Z A Cohn
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307

8.  Macrophage stimulation by bacterial lipopolysaccharides. I. Cytolytic effect on tumor target cells.

Authors:  W F Doe; P M Henson
Journal:  J Exp Med       Date:  1978-08-01       Impact factor: 14.307

9.  Synthesis of the second component of complement by long-term primary cultures of human monocytes.

Authors:  L P Einstein; E E Schneeberger; H R Colten
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307
  9 in total

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