Literature DB >> 11943848

NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.

Rami Yaka1, Claire Thornton, Alicia J Vagts, Khanhky Phamluong, Antonello Bonci, Dorit Ron.   

Abstract

Phosphorylation regulates the function of ligand-gated ion channels such as the N-methyl d-aspartate (NMDA) receptor. Here we report a mechanism for modulation of the phosphorylation state and function of the NMDA receptor via an inhibitory scaffolding protein, RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase, Fyn. RACK1 inhibits Fyn phosphorylation of NR2B and decreases NMDA receptor-mediated currents in CA1 hippocampal slices. Peptides that disrupt the interactions between RACK1, NR2B, and Fyn induce phosphorylation and potentiate NMDA receptor-mediated currents. Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory.

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Year:  2002        PMID： 11943848      PMCID： PMC122836          DOI： 10.1073/pnas.062046299

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

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Authors:  T Mourton; C B Hellberg; S M Burden-Gulley; J Hinman; A Rhee; S M Brady-Kalnay
Journal:  J Biol Chem       Date:  2001-02-13       Impact factor: 5.157

2.  Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.

Authors:  H Husi; M A Ward; J S Choudhary; W P Blackstock; S G Grant
Journal:  Nat Neurosci       Date:  2000-07       Impact factor: 24.884

3.  Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.

Authors:  T Nakazawa; S Komai; T Tezuka; C Hisatsune; H Umemori; K Semba; M Mishina; T Manabe; T Yamamoto
Journal:  J Biol Chem       Date:  2001-01-05       Impact factor: 5.157

4.  Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.

Authors:  H Monyer; N Burnashev; D J Laurie; B Sakmann; P H Seeburg
Journal:  Neuron       Date:  1994-03       Impact factor: 17.173

5.  The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.

Authors:  I S Moon; M L Apperson; M B Kennedy
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

6.  Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors.

Authors:  N J Brandon; J M Uren; J T Kittler; H Wang; R Olsen; P J Parker; S J Moss
Journal:  J Neurosci       Date:  1999-11-01       Impact factor: 6.167

7.  Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.

Authors:  N Geijsen; M Spaargaren; J A Raaijmakers; J W Lammers; L Koenderman; P J Coffer
Journal:  Oncogene       Date:  1999-09-09       Impact factor: 9.867

8.  Identification of proteins in the postsynaptic density fraction by mass spectrometry.

Authors:  R S Walikonis; O N Jensen; M Mann; D W Provance; J A Mercer; M B Kennedy
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

9.  Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Authors:  D Ron; C H Chen; J Caldwell; L Jamieson; E Orr; D Mochly-Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

10.  Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

Authors:  S G Grant; T J O'Dell; K A Karl; P L Stein; P Soriano; E R Kandel
Journal:  Science       Date:  1992-12-18       Impact factor: 47.728
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  78 in total

1.  A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.

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Journal:  J Neurosci       Date:  2002-10-15       Impact factor: 6.167

2.  The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1.

Authors:  Graeme B Bolger
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3.  Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol.

Authors:  Rami Yaka; Khanhky Phamluong; Dorit Ron
Journal:  J Neurosci       Date:  2003-05-01       Impact factor: 6.167

Review 4.  Signaling cascades regulating NMDA receptor sensitivity to ethanol.

Authors:  Dorit Ron
Journal:  Neuroscientist       Date:  2004-08       Impact factor: 7.519

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Authors:  Randen L Patterson; Damian B van Rossum; Roxanne K Barrow; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-24       Impact factor: 11.205

6.  Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.

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Journal:  J Biol Chem       Date:  2011-12-15       Impact factor: 5.157

Review 7.  Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia.

Authors:  Michael W Salter; Graham M Pitcher
Journal:  FEBS J       Date:  2011-12-05       Impact factor: 5.542

Review 8.  Glutamate receptor ion channels: structure, regulation, and function.

Authors:  Stephen F Traynelis; Lonnie P Wollmuth; Chris J McBain; Frank S Menniti; Katie M Vance; Kevin K Ogden; Kasper B Hansen; Hongjie Yuan; Scott J Myers; Ray Dingledine
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9.  Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption.

Authors:  Emmanuel Darcq; Sami Ben Hamida; Su Wu; Khanky Phamluong; Viktor Kharazia; Jian Xu; Paul Lombroso; Dorit Ron
Journal:  J Neurochem       Date:  2014-03-27       Impact factor: 5.372

10.  RACK1 regulates Src activity and modulates paxillin dynamics during cell migration.

Authors:  Ashley T Doan; Anna Huttenlocher
Journal:  Exp Cell Res       Date:  2007-05-18       Impact factor: 3.905
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