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Literature DB >> 15271260

Signaling cascades regulating NMDA receptor sensitivity to ethanol.

Abstract

One of the major targets for ethanol (alcohol) in the brain is the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel. Intriguingly, the effects of ethanol on the NMDA receptor are not homogeneous throughout the brain. This review focuses on recent studies revealing molecular mechanisms that mediate the actions of ethanol on the NMDA receptor in different brain regions via changes in NMDA receptor phosphorylation and compartmentalization. Specifically, the role of the scaffolding protein RACK1 and the regulatory protein DARPP-32 in mediating the distinct effects of ethanol is presented.

Entities: Chemical Gene

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Year: 2004 PMID： 15271260 PMCID： PMC1361309 DOI： 10.1177/1073858404263516

Source DB: PubMed Journal: Neuroscientist ISSN： 1073-8584 Impact factor: 7.519

121 in total

1. The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts.

Authors: T Mourton; C B Hellberg; S M Burden-Gulley; J Hinman; A Rhee; S M Brady-Kalnay
Journal: J Biol Chem Date: 2001-02-13 Impact factor: 5.157

2. Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.

Authors: G Y Liao; D A Wagner; M H Hsu; J P Leonard
Journal: Mol Pharmacol Date: 2001-05 Impact factor: 4.436

Review 3. NMDA receptor subunits: diversity, development and disease.

Authors: S Cull-Candy; S Brickley; M Farrant
Journal: Curr Opin Neurobiol Date: 2001-06 Impact factor: 6.627

4. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing.

Authors: D B Scott; T A Blanpied; G T Swanson; C Zhang; M D Ehlers
Journal: J Neurosci Date: 2001-05-01 Impact factor: 6.167

5. Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor.

Authors: D R Grosshans; M D Browning
Journal: J Neurochem Date: 2001-02 Impact factor: 5.372

6. Motivational effects of ethanol in DARPP-32 knock-out mice.

Authors: F O Risinger; P A Freeman; P Greengard; A A Fienberg
Journal: J Neurosci Date: 2001-01-01 Impact factor: 6.167

7. CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus.

Authors: Y Huang; W Lu; D W Ali; K A Pelkey; G M Pitcher; Y M Lu; H Aoto; J C Roder; T Sasaki; M W Salter; J F MacDonald
Journal: Neuron Date: 2001-02 Impact factor: 17.173

8. Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane.

Authors: A W Dunah; D G Standaert
Journal: J Neurosci Date: 2001-08-01 Impact factor: 6.167

9. Interaction with the NMDA receptor locks CaMKII in an active conformation.

Authors: K U Bayer; P De Koninck; A S Leonard; J W Hell; H Schulman
Journal: Nature Date: 2001-06-14 Impact factor: 49.962

10. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.

Authors: F Gardoni; C Bellone; F Cattabeni; M Di Luca
Journal: J Biol Chem Date: 2000-12-04 Impact factor: 5.157

49 in total

1. Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.

Authors: Jungwoo Yang; Qian Wang; Wang Zheng; Jagdeep Tuli; Qiang Li; Yuliang Wu; Shaimaa Hussein; Xiao-Qing Dai; Shiva Shafiei; Xiao-Gai Li; Patrick Y Shen; Jian-Cheng Tu; Xing-Zhen Chen
Journal: J Biol Chem Date: 2011-12-15 Impact factor: 5.157

Review 2. Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury.

Authors: Mark A Prendergast; Patrick J Mulholland
Journal: Addict Biol Date: 2011-10-04 Impact factor: 4.280

Review 3. Adenosine and glutamate signaling in neuron-glial interactions: implications in alcoholism and sleep disorders.

Authors: Hyung W Nam; Sally R McIver; David J Hinton; Mahesh M Thakkar; Youssef Sari; Fiona E Parkinson; Phillip G Haydon; Doo-Sup Choi
Journal: Alcohol Clin Exp Res Date: 2012-02-06 Impact factor: 3.455

4. Positions in the N-methyl-D-aspartate Receptor GluN2C Subunit M3 and M4 Domains Regulate Alcohol Sensitivity and Receptor Kinetics.

Authors: Man Wu; Priya Katti; Yulin Zhao; Robert W Peoples
Journal: Alcohol Clin Exp Res Date: 2019-04-30 Impact factor: 3.455

Review 5. Glutamatergic targets for new alcohol medications.

Authors: Andrew Holmes; Rainer Spanagel; John H Krystal
Journal: Psychopharmacology (Berl) Date: 2013-09-01 Impact factor: 4.530

6. Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors.

Authors: Daryl L Davies; Liana Asatryan; Sacha T Kuo; John J Woodward; Brian F King; Ronald L Alkana; Cheng Xiao; Jiang Hong Ye; Hui Sun; Li Zhang; Xiang-Qun Hu; Volodya Hayrapetyan; David M Lovinger; Tina K Machu
Journal: Alcohol Clin Exp Res Date: 2006-02 Impact factor: 3.455