Literature DB >> 14983009

RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release.

Randen L Patterson1, Damian B van Rossum, Roxanne K Barrow, Solomon H Snyder.   

Abstract

RACK1 is not a G protein but closely resembles the heterotrimeric Gbeta-subunit. RACK1 serves as a scaffold, linking protein kinase C to its substrates. We demonstrate that RACK1 physiologically binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. Overexpression of RACK1 or depletion of RACK1 by interference RNA markedly augments or diminishes Ca2+ release, respectively, without affecting Ca2+ entry. These findings establish RACK1 as a physiologic mediator of agonist-induced Ca2+ release.

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Year:  2004        PMID： 14983009      PMCID： PMC356950          DOI： 10.1073/pnas.0308567100

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

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