Literature DB >> 11932431

Scrapie infectivity in hamster blood is not associated with platelets.

Karel Holada1, Jaroslav G Vostal, Patrick W Theisen, Claudia MacAuley, Luisa Gregori, Robert G Rohwer.   

Abstract

The infectivity of hamster scrapie strain 263K was measured in platelets isolated from blood pooled from six hamsters with clinical scrapie. The total number of infectious doses present in the blood pool was 220, out of which only 3.5 infectious doses were associated with platelets. A larger proportion of the total infectivity was recovered from the mononuclear leukocyte fraction. This result indicates that platelets are not the source of blood-borne infectivity in transmissible spongiform encephalopathy-infected hamsters.

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Year:  2002        PMID： 11932431      PMCID： PMC155088          DOI： 10.1128/jvi.76.9.4649-4650.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  10 in total

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