Literature DB >> 16825571

Prion-induced amyloid heart disease with high blood infectivity in transgenic mice.

Matthew J Trifilo1, Toshitaka Yajima, Yusu Gu, Nancy Dalton, Kirk L Peterson, Richard E Race, Kimberly Meade-White, John L Portis, Eliezer Masliah, Kirk U Knowlton, Bruce Chesebro, Michael B A Oldstone.   

Abstract

We investigated extraneural manifestations in scrapie-infected transgenic mice expressing prion protein lacking the glycophosphatydylinositol membrane anchor. In the brain, blood, and heart, both abnormal protease-resistant prion protein (PrPres) and prion infectivity were readily detected by immunoblot and by inoculation into nontransgenic recipients. The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease.

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Year:  2006        PMID： 16825571      PMCID： PMC1820586          DOI： 10.1126/science.1128635

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Codon 129 prion protein genotype and sporadic Creutzfeldt-Jakob disease.

Authors:  A Alperovitch; I Zerr; M Pocchiari; E Mitrova; J de Pedro Cuesta; I Hegyi; S Collins; H Kretzschmar; C van Duijn; R G Will
Journal:  Lancet       Date:  1999-05-15       Impact factor: 79.321

2.  Anchorless prion protein results in infectious amyloid disease without clinical scrapie.

Authors:  Bruce Chesebro; Matthew Trifilo; Richard Race; Kimberly Meade-White; Chao Teng; Rachel LaCasse; Lynne Raymond; Cynthia Favara; Gerald Baron; Suzette Priola; Byron Caughey; Eliezer Masliah; Michael Oldstone
Journal:  Science       Date:  2005-06-03       Impact factor: 47.728

3.  Prion-associated dilated cardiomyopathy.

Authors:  Mahi Lakshmi Ashwath; Stephen J Dearmond; Talley Culclasure
Journal:  Arch Intern Med       Date:  2005-02-14

4.  Levels of infectivity in the blood throughout the incubation period of hamsters peripherally injected with scrapie.

Authors:  P Casaccia; A Ladogana; Y G Xi; M Pocchiari
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

5.  PrPTSE distribution in a primate model of variant, sporadic, and iatrogenic Creutzfeldt-Jakob disease.

Authors:  Christian Herzog; Julie Rivière; Nathalie Lescoutra-Etchegaray; Aurore Charbonnier; Virginie Leblanc; Nicole Salès; Jean-Philippe Deslys; Corinne Ida Lasmézas
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

6.  Chronic lymphocytic inflammation specifies the organ tropism of prions.

Authors:  Mathias Heikenwalder; Nicolas Zeller; Harald Seeger; Marco Prinz; Peter-Christian Klöhn; Petra Schwarz; Nancy H Ruddle; Charles Weissmann; Adriano Aguzzi
Journal:  Science       Date:  2005-01-20       Impact factor: 47.728

7.  The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy.

Authors:  P Brown; R G Rohwer; B C Dunstan; C MacAuley; D C Gajdusek; W N Drohan
Journal:  Transfusion       Date:  1998-09       Impact factor: 3.157

8.  Detection of prions in blood.

Authors:  Joaquín Castilla; Paula Saá; Claudio Soto
Journal:  Nat Med       Date:  2005-08-28       Impact factor: 53.440

Review 9.  Diagnosis and treatment of heart failure based on left ventricular systolic or diastolic dysfunction.

Authors:  W H Gaasch
Journal:  JAMA       Date:  1994-04-27       Impact factor: 56.272

10.  Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient.

Authors:  Alexander H Peden; Mark W Head; Diane L Ritchie; Jeanne E Bell; James W Ironside
Journal:  Lancet       Date:  2004 Aug 7-13       Impact factor: 79.321
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  28 in total

Review 1.  Emergence and natural selection of drug-resistant prions.

Authors:  James Shorter
Journal:  Mol Biosyst       Date:  2010-04-27

2.  Shedding light on prion disease.

Authors:  Markus Glatzel; Luise Linsenmeier; Frank Dohler; Susanne Krasemann; Berta Puig; Hermann C Altmeppen
Journal:  Prion       Date:  2015       Impact factor: 3.931

3.  Increased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion protein.

Authors:  Brent Race; Katie Phillips; Kimberly Meade-White; James Striebel; Bruce Chesebro
Journal:  J Virol       Date:  2015-03-25       Impact factor: 5.103

4.  Ultrastructure and pathology of prion protein amyloid accumulation and cellular damage in extraneural tissues of scrapie-infected transgenic mice expressing anchorless prion protein.

Authors:  Brent Race; Martin Jeffrey; Gillian McGovern; David Dorward; Bruce Chesebro
Journal:  Prion       Date:  2017-07-31       Impact factor: 3.931

Review 5.  Prions: Beyond a Single Protein.

Authors:  Alvin S Das; Wen-Quan Zou
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

6.  Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection.

Authors:  Mikael Klingeborn; Brent Race; Kimberly D Meade-White; Rebecca Rosenke; James F Striebel; Bruce Chesebro
Journal:  J Virol       Date:  2010-12-01       Impact factor: 5.103

7.  Extraneural manifestations of prion infection in GPI-anchorless transgenic mice.

Authors:  Andrew M Lee; Johan F Paulsson; Justin Cruite; Abegail A Andaya; Matthew J Trifilo; Michael B A Oldstone
Journal:  Virology       Date:  2011-01-11       Impact factor: 3.616

8.  Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway.

Authors:  Matthew J Trifilo; Manuel Sanchez-Alavez; Laura Solforosi; Joie Bernard-Trifilo; Stefan Kunz; Dorian McGavern; Michael B A Oldstone
Journal:  J Virol       Date:  2008-07-30       Impact factor: 5.103

9.  Chronic wasting disease of deer and elk in transgenic mice: oral transmission and pathobiology.

Authors:  Matthew J Trifilo; Ge Ying; Chao Teng; Michael B A Oldstone
Journal:  Virology       Date:  2007-04-23       Impact factor: 3.616

10.  Functionally relevant domains of the prion protein identified in vivo.

Authors:  Frank Baumann; Jens Pahnke; Ivan Radovanovic; Thomas Rülicke; Juliane Bremer; Markus Tolnay; Adriano Aguzzi
Journal:  PLoS One       Date:  2009-09-07       Impact factor: 3.240
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