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Literature DB >> 1191703

Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitro.

G L Gianfranceschi, D Amici, L Guglielmi.

Abstract

A thymic factor causes a strong inhibition of the DNA-directed RNA polymerase reaction in vitro. The active factor was isolated from aqueous ultrafiltered thymus extracts and purified by means of chromatography on DEAE-cellulose and then on Dowex 50 WX2. The purified thymic factor was characterized as a peptide of low molecular weight (less than 5000). The biological activity of the thymic factor cannot be attributed to the presence of a nuclease or of a histone fragment. The RNA synthesis is controlled by this factor by means of electrostatic interactions between the peptide compound and DNA. Inhibitory activity on RNA synthesis was absent from kidney extracts.

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Year: 1975 PMID： 1191703 DOI： 10.1016/0005-2787(75)90121-5

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

16 in total

1. Stabilization of double-stranded DNA molecule by non-histone peptidic effector from calf thymus.

Authors: G L Gianfranceschi; D Amici; L Guglielmi
Journal: Mol Biol Rep Date: 1976-09 Impact factor: 2.316

2. Small acidic peptides are bound to E. coli DNA.

Authors: F Felici; E Cardellini; A Miano; M Bramucci; G Piccinini; D Amici; G L Gianfranceschi
Journal: Mol Biol Rep Date: 1991-02 Impact factor: 2.316

3. Specific thymic peptides-DNA interaction. Correlation with the possible stereochemical kinking scheme of DNA.

Authors: L Guglielmi; G L Gianfranceschi; F Venanzi; A Polzonetti; D Amici
Journal: Mol Biol Rep Date: 1979-02-15 Impact factor: 2.316

4. Control of RNA and protein synthesis in phytohemagglutinin-stimulated human lymphocytes by chromatin peptides from calf thymus.

Authors: D Amici; G L Gianfranceschi
Journal: Mol Biol Rep Date: 1980-12-31 Impact factor: 2.316

5. Isolation and characterization of DNA-binding peptides from the serum: inhibition of transcription and comparison with the tissue peptides.

Authors: D Amici; D Barra; M Hillar; O Murri; F Cicconi; G L Gianfranceschi
Journal: Mol Biol Rep Date: 1982-11-30 Impact factor: 2.316

6. DNA-binding peptides from rat liver and Novikoff hepatoma cells: quantitative level and possible biochemical differences.

Authors: G L Gianfranceschi; D Barra; S Coderoni; M Paparelli; F Venanzi; D Amici
Journal: Mol Biol Rep Date: 1983-08 Impact factor: 2.316

Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitro.

1. Stabilization of double-stranded DNA molecule by non-histone peptidic effector from calf thymus.

2. Small acidic peptides are bound to E. coli DNA.

3. Specific thymic peptides-DNA interaction. Correlation with the possible stereochemical kinking scheme of DNA.

4. Control of RNA and protein synthesis in phytohemagglutinin-stimulated human lymphocytes by chromatin peptides from calf thymus.

5. Isolation and characterization of DNA-binding peptides from the serum: inhibition of transcription and comparison with the tissue peptides.

6. DNA-binding peptides from rat liver and Novikoff hepatoma cells: quantitative level and possible biochemical differences.

7. Thymic control of the polyploidization of hepatocytes during aging.

8. Nuclear deprimerones in rat liver and Novikoff hepatoma.

9. Inhibition of exogenous mRNA translation in a cell-free system by chromatin peptides from calf thymus.

10. Insulin receptors in mouse brain: Reversibility of age-related impairments by a thymic extract.