| Literature DB >> 11896235 |
Olen Kew1, Victoria Morris-Glasgow, Mauricio Landaverde, Cara Burns, Jing Shaw, Zacarías Garib, Jean André, Elizabeth Blackman, C Jason Freeman, Jaume Jorba, Roland Sutter, Gina Tambini, Linda Venczel, Cristina Pedreira, Fernando Laender, Hiroyuki Shimizu, Tetsuo Yoneyama, Tatsuo Miyamura, Harrie van Der Avoort, M Steven Oberste, David Kilpatrick, Stephen Cochi, Mark Pallansch, Ciro de Quadros.
Abstract
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.Entities:
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Year: 2002 PMID： 11896235 DOI： 10.1126/science.1068284
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728