Literature DB >> 11894912

The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a.

J L Bos1, H C ten Wolde-Kraamwinkel.   

Abstract

We have investigated the effect of the E1a region of adenovirus on the expression of the E1b transcriptional unit in mouse L tk- cells. To that end we have fused the promoter region of the E1b gene of Ad12 to the coding sequence of the thymidine kinase gene of herpes simplex virus type 1. We found that expression of this fusion gene is completely dependent on the presence of the E1a region. Sequences involved in this regulation were mapped between positions -135 and +11 from the E1b cap site. In addition, we found that the largest E1a protein is essential in this regulation process.

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Year:  1983        PMID： 11894912      PMCID： PMC555089          DOI： 10.1002/j.1460-2075.1983.tb01383.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  14 in total

1.  Control of adenovirus early gene expression: posttranscriptional control mediated by both viral and cellular gene products.

Authors:  M G Katze; H Persson; L Philipson
Journal:  Mol Cell Biol       Date:  1981-09       Impact factor: 4.272

2.  An adenovirus type 5 early gene function regulates expression of other early viral genes.

Authors:  N Jones; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

3.  Mapping of adenovirus 12 mRNA's transcribed from the transforming region.

Authors:  Y Sawada; K Fujinaga
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

4.  Structure and function of the transforming genes of human adenoviruses and SV40.

Authors:  A J van der Eb; H van Ormondt; P I Schrier; J H Lupker; H Jochemsen; P J van den Elsen; R J DeLeys; J Maat; C P van Beveren; R Dijkema; A de Waard
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1980

5.  Assay of transforming activity of tumor virus DNA.

Authors:  A J van der Eb; F L Graham
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

6.  The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets.

Authors:  J L Bos; L J Polder; R Bernards; P I Schrier; P J van den Elsen; A J van der Eb; H van Ormondt
Journal:  Cell       Date:  1981-11       Impact factor: 41.582

7.  Transformation-defective mutant of adenovirus type 5 containing a single altered E1a mRNA species.

Authors:  L R Carlock; N C Jones
Journal:  J Virol       Date:  1981-12       Impact factor: 5.103

8.  Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs.

Authors:  A J Berk; F Lee; T Harrison; J Williams; P A Sharp
Journal:  Cell       Date:  1979-08       Impact factor: 41.582

9.  Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1.

Authors:  N M Wilkie; J B Clements; W Boll; N Mantei; D Lonsdale; C Weissmann
Journal:  Nucleic Acids Res       Date:  1979-10-25       Impact factor: 16.971

10.  Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

Authors:  R P Ricciardi; R L Jones; C L Cepko; P A Sharp; B E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205
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  27 in total

1.  Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.

Authors:  D J Slamon; W J Boyle; D E Keith; M F Press; D W Golde; L M Souza
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

Review 2.  Expression and interactions of human adenovirus oncoproteins.

Authors:  P A Boulanger; G E Blair
Journal:  Biochem J       Date:  1991-04-15       Impact factor: 3.857

3.  cis-dominant defect in activation of adenovirus type 5 E1b early RNA synthesis.

Authors:  C L Parks; D J Spector
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

4.  Organization of the transcriptional control region of the E1b gene of adenovirus type 5.

Authors:  C L Parks; S Banerjee; D J Spector
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

5.  A specific domain of the adenovirus EIV promoter is necessary to maintain susceptibility of the integrated promoter to EIA transactivation.

Authors:  T Nishigaki; S Hanaka; R E Kingston; H Handa
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

6.  The abundance and in vitro DNA binding of three cellular proteins interacting with the adenovirus EIIa early promoter are not modified by the EIa gene products.

Authors:  P Jalinot; B Devaux; C Kédinger
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

Review 7.  The structure and functions of the adenovirus early region 1 proteins.

Authors:  R J Grand
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

8.  Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit.

Authors:  P Sassone-Corsi; R Hen; E Borrelli; T Leff; P Chambon
Journal:  Nucleic Acids Res       Date:  1983-12-20       Impact factor: 16.971

9.  Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation.

Authors:  M J Imperiale; J R Nevins
Journal:  Mol Cell Biol       Date:  1984-05       Impact factor: 4.272

10.  Different activities of the adenovirus types 5 and 12 E1A regions in transformation with the EJ Ha-ras oncogene.

Authors:  A G Jochemsen; R Bernards; H J van Kranen; A Houweling; J L Bos; A J van der Eb
Journal:  J Virol       Date:  1986-09       Impact factor: 5.103
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