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Literature DB >> 11891318

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus.

Bernice Porjesz¹, Laura Almasy, Howard J Edenberg, Kongming Wang, David B Chorlian, Tatiana Foroud, Alison Goate, John P Rice, Sean J O'Connor, John Rohrbaugh, Samuel Kuperman, Lance O Bauer, Raymond R Crowe, Marc A Schuckit, Victor Hesselbrock, P Michael Conneally, Jay A Tischfield, Ting-Kai Li, Theodore Reich, Henri Begleiter.

Abstract

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by gamma-aminobutyric acid type A (GABA(A)) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA(A) receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2002 PMID： 11891318 PMCID： PMC122592 DOI： 10.1073/pnas.052716399

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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