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Literature DB >> 11282419

GABA(A) receptor subtypes: dissecting their pharmacological functions.

Abstract

The enhancement of GABA-mediated synaptic transmission underlies the pharmacotherapy of various neurological and psychiatric disorders. GABA(A) receptors are pluripotent drug targets that display an extraordinary structural heterogeneity: they are assembled from a repertoire of at least 18 subunits (alpha1-6, beta1-3, gamma1-3, delta, epsilon, theta, rho1-3). However, differentiating defined GABA(A) receptor subtypes on the basis of function has had to await recent progress in the genetic dissection of receptor subtypes in vivo. Evidence that the various actions of allosteric modulators of GABA(A) receptors, in particular the benzodiazepines, can be attributed to specific GABA(A) receptor subtypes will be discussed. Such discoveries could open up new avenues for drug development.

Entities: Chemical Disease Gene

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Year: 2001 PMID： 11282419 DOI： 10.1016/s0165-6147(00)01646-1

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

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Cited

108 in total

Review 1. Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission.

Authors: Josef T Kittler; Kristina McAinsh; Stephen J Moss
Journal: Mol Neurobiol Date: 2002 Oct-Dec Impact factor: 5.590

2. Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype.

Authors: I Tobler; C Kopp; T Deboer; U Rudolph
Journal: Proc Natl Acad Sci U S A Date: 2001-05-15 Impact factor: 11.205

3. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.

Authors: Alberto Bacci; Uwe Rudolph; John R Huguenard; David A Prince
Journal: J Neurosci Date: 2003-10-22 Impact factor: 6.167

Review 4. CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention.

Authors: Karl-Erik Andersson; Rikard Pehrson
Journal: Drugs Date: 2003 Impact factor: 9.546

5. Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

Authors: Frédéric Minier; Erwin Sigel
Journal: Proc Natl Acad Sci U S A Date: 2004-05-10 Impact factor: 11.205

6. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

Authors: Bradford D Fischer; Stephanie C Licata; Rahul V Edwankar; Zhi-Jian Wang; Shengming Huang; Xiaohui He; Jianming Yu; Hao Zhou; Edward M Johnson; James M Cook; Roman Furtmüller; Joachim Ramerstorfer; Werner Sieghart; Bryan L Roth; Samarpan Majumder; James K Rowlett
Journal: Neuropharmacology Date: 2010-08-18 Impact factor: 5.250

7. Model-based meta-analysis of the effects of non-selective and α1-selective GABAA receptor agonists in healthy volunteers.

Authors: Yu-Peng Ren; Ru-Jia Xie; Scott Marshall; Liang Li; Tian-Yan Zhou; Wei Lu
Journal: Eur J Clin Pharmacol Date: 2015-08-11 Impact factor: 2.953

GABA(A) receptor subtypes: dissecting their pharmacological functions.

Review 1. Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission.

2. Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype.

3. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.

Review 4. CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention.

5. Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

6. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

7. Model-based meta-analysis of the effects of non-selective and α1-selective GABAA receptor agonists in healthy volunteers.

Review 8. GABA_A receptor polymorphisms in alcohol use disorder in the GWAS era.

9. Age-related GABAA receptor changes in rat auditory cortex.

10. Tonic GABAA receptor-mediated inhibition in the rat dorsal motor nucleus of the vagus.

Review 1. Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission.

Review 4. CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention.

Review 8. GABAA receptor polymorphisms in alcohol use disorder in the GWAS era.

Review 8. GABA_A receptor polymorphisms in alcohol use disorder in the GWAS era.