Literature DB >> 11875207

Complexity and robustness.

J M Carlson1, John Doyle.   

Abstract

Highly optimized tolerance (HOT) was recently introduced as a conceptual framework to study fundamental aspects of complexity. HOT is motivated primarily by systems from biology and engineering and emphasizes, (i) highly structured, nongeneric, self-dissimilar internal configurations, and (ii) robust yet fragile external behavior. HOT claims these are the most important features of complexity and not accidents of evolution or artifices of engineering design but are inevitably intertwined and mutually reinforcing. In the spirit of this collection, our paper contrasts HOT with alternative perspectives on complexity, drawing on real-world examples and also model systems, particularly those from self-organized criticality.

Entities:  

Year:  2002        PMID: 11875207      PMCID: PMC128573          DOI: 10.1073/pnas.012582499

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  10 in total

1.  Reexamining fire suppression impacts on brushland fire regimes

Authors: 
Journal:  Science       Date:  1999-06-11       Impact factor: 47.728

2.  Robust perfect adaptation in bacterial chemotaxis through integral feedback control.

Authors:  T M Yi; Y Huang; M I Simon; J Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

3.  Dynamics and changing environments in highly optimized tolerance

Authors: 
Journal:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics       Date:  2000-09

4.  Mutation, specialization, and hypersensitivity in highly optimized tolerance.

Authors:  Tong Zhou; J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

5.  Complexity, contingency, and criticality.

Authors:  P Bak; M Paczuski
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

6.  Highly optimized tolerance: a mechanism for power laws in designed systems.

Authors:  J M Carlson; J Doyle
Journal:  Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics       Date:  1999-08

7.  Power laws, highly optimized tolerance, and generalized source coding

Authors: 
Journal:  Phys Rev Lett       Date:  2000-06-12       Impact factor: 9.161

8.  Highly optimized tolerance: robustness and design in complex systems

Authors: 
Journal:  Phys Rev Lett       Date:  2000-03-13       Impact factor: 9.161

9.  Self-organized critical forest-fire model.

Authors: 
Journal:  Phys Rev Lett       Date:  1992-09-14       Impact factor: 9.161

10.  Forest fires: An example of self-organized critical behavior

Authors: 
Journal:  Science       Date:  1998-09-18       Impact factor: 47.728

  10 in total
  98 in total

1.  Mutation, specialization, and hypersensitivity in highly optimized tolerance.

Authors:  Tong Zhou; J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

2.  Self-organized complexity in the physical, biological, and social sciences.

Authors:  Donald L Turcotte; John B Rundle
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

3.  Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle.

Authors:  Ling Yang; W Robb MacLellan; Zhangang Han; James N Weiss; Zhilin Qu
Journal:  Biophys J       Date:  2004-06       Impact factor: 4.033

4.  Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis.

Authors:  M Bentele; I Lavrik; M Ulrich; S Stösser; D W Heermann; H Kalthoff; P H Krammer; R Eils
Journal:  J Cell Biol       Date:  2004-09-13       Impact factor: 10.539

5.  Robustness properties of circadian clock architectures.

Authors:  Jörg Stelling; Ernst Dieter Gilles; Francis J Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-30       Impact factor: 11.205

Review 6.  Integration of metabolic reactions and gene regulation.

Authors:  Chen-Hsiang Yeang
Journal:  Mol Biotechnol       Date:  2011-01       Impact factor: 2.695

Review 7.  Integration of structural dynamics and molecular evolution via protein interaction networks: a new era in genomic medicine.

Authors:  Avishek Kumar; Brandon M Butler; Sudhir Kumar; S Banu Ozkan
Journal:  Curr Opin Struct Biol       Date:  2015-12-09       Impact factor: 6.809

8.  The "robust yet fragile" nature of the Internet.

Authors:  John C Doyle; David L Alderson; Lun Li; Steven Low; Matthew Roughan; Stanislav Shalunov; Reiko Tanaka; Walter Willinger
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-04       Impact factor: 11.205

9.  Wildfires, complexity, and highly optimized tolerance.

Authors:  Max A Moritz; Marco E Morais; Lora A Summerell; J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-06       Impact factor: 11.205

10.  Multiple feedback loop design in the tryptophan regulatory network of Escherichia coli suggests a paradigm for robust regulation of processes in series.

Authors:  Sharad Bhartiya; Nikhil Chaudhary; K V Venkatesh; Francis J Doyle
Journal:  J R Soc Interface       Date:  2006-06-22       Impact factor: 4.118

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