Literature DB >> 11018927

Highly optimized tolerance: robustness and design in complex systems

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Abstract

Highly optimized tolerance (HOT) is a mechanism that relates evolving structure to power laws in interconnected systems. HOT systems arise where design and evolution create complex systems sharing common features, including (1) high efficiency, performance, and robustness to designed-for uncertainties, (2) hypersensitivity to design flaws and unanticipated perturbations, (3) nongeneric, specialized, structured configurations, and (4) power laws. We study the impact of incorporating increasing levels of design and find that even small amounts of design lead to HOT states in percolation.

Entities:  

Year:  2000        PMID: 11018927     DOI: 10.1103/PhysRevLett.84.2529

Source DB:  PubMed          Journal:  Phys Rev Lett        ISSN: 0031-9007            Impact factor:   9.161


  33 in total

1.  Mutation, specialization, and hypersensitivity in highly optimized tolerance.

Authors:  Tong Zhou; J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

2.  Complexity and robustness.

Authors:  J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

3.  Small-world communication of residues and significance for protein dynamics.

Authors:  Ali Rana Atilgan; Pelin Akan; Canan Baysal
Journal:  Biophys J       Date:  2004-01       Impact factor: 4.033

4.  Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy.

Authors:  Brian J Park; Zakary L Whichard; Seth J Corey
Journal:  Cancer Lett       Date:  2012-02-02       Impact factor: 8.679

5.  Wildfires, complexity, and highly optimized tolerance.

Authors:  Max A Moritz; Marco E Morais; Lora A Summerell; J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-06       Impact factor: 11.205

Review 6.  Systems interface biology.

Authors:  Francis J Doyle; Jörg Stelling
Journal:  J R Soc Interface       Date:  2006-10-22       Impact factor: 4.118

7.  Sensitivity Measures for Oscillating Systems: Application to Mammalian Circadian Gene Network.

Authors:  Stephanie R Taylor; Rudiyanto Gunawan; Linda R Petzold; Francis J Doyle
Journal:  IEEE Trans Automat Contr       Date:  2008-01-01       Impact factor: 5.792

Review 8.  Pervasive robustness in biological systems.

Authors:  Marie-Anne Félix; Michalis Barkoulas
Journal:  Nat Rev Genet       Date:  2015-08       Impact factor: 53.242

Review 9.  Kinetic Modeling of Virus Growth in Cells.

Authors:  John Yin; Jacob Redovich
Journal:  Microbiol Mol Biol Rev       Date:  2018-03-28       Impact factor: 11.056

10.  Of mice and men: bridging the translational disconnect in CNS drug discovery.

Authors:  Hugo Geerts
Journal:  CNS Drugs       Date:  2009-11       Impact factor: 5.749

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