Literature DB >> 11872829

Systems biology: a brief overview.

Hiroaki Kitano1.   

Abstract

To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central issues, and understanding these properties may have an impact on the future of medicine. However, many breakthroughs in experimental devices, advanced software, and analytical methods are required before the achievements of systems biology can live up to their much-touted potential.

Mesh：

Year:  2002        PMID： 11872829     DOI： 10.1126/science.1069492

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  820 in total

Review 1.  Human cardiac systems electrophysiology and arrhythmogenesis: iteration of experiment and computation.

Authors:  Katherine M Holzem; Eli J Madden; Igor R Efimov
Journal:  Europace       Date:  2014-11       Impact factor: 5.214

2.  Fractal analysis in a systems biology approach to cancer.

Authors:  M Bizzarri; A Giuliani; A Cucina; F D'Anselmi; A M Soto; C Sonnenschein
Journal:  Semin Cancer Biol       Date:  2011-04-13       Impact factor: 15.707

Review 3.  Genome informatics: current status and future prospects.

Authors:  Raimond L Winslow; Mark S Boguski
Journal:  Circ Res       Date:  2003-05-16       Impact factor: 17.367

Review 4.  High throughput gene expression profiling: a molecular approach to integrative physiology.

Authors:  Mingyu Liang; Allen W Cowley; Andrew S Greene
Journal:  J Physiol       Date:  2004-01-01       Impact factor: 5.182

5.  A computer-based microarray experiment design-system for gene-regulation pathway discovery.

Authors:  Changwon Yoo; Gregory F Cooper
Journal:  AMIA Annu Symp Proc       Date:  2003

6.  Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling.

Authors:  I Swameye; T G Muller; J Timmer; O Sandra; U Klingmuller
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-27       Impact factor: 11.205

7.  Optimal Objective-Based Experimental Design for Uncertain Dynamical Gene Networks with Experimental Error.

Authors:  Daniel N Mohsenizadeh; Roozbeh Dehghannasiri; Edward R Dougherty
Journal:  IEEE/ACM Trans Comput Biol Bioinform       Date:  2016-08-25       Impact factor: 3.710

8.  Human ORFeome version 1.1: a platform for reverse proteomics.

Authors:  Jean-François Rual; Tomoko Hirozane-Kishikawa; Tong Hao; Nicolas Bertin; Siming Li; Amélie Dricot; Ning Li; Jennifer Rosenberg; Philippe Lamesch; Pierre-Olivier Vidalain; Tracey R Clingingsmith; James L Hartley; Dominic Esposito; David Cheo; Troy Moore; Blake Simmons; Reynaldo Sequerra; Stephanie Bosak; Lynn Doucette-Stamm; Christian Le Peuch; Jean Vandenhaute; Michael E Cusick; Joanna S Albala; David E Hill; Marc Vidal
Journal:  Genome Res       Date:  2004-10       Impact factor: 9.043

9.  A Gateway between Omics Data and Systems Biology.

Authors:  Fabian V Filipp
Journal:  J Metabolomics Syst Biol       Date:  2013-11-01

Review 10.  Integrating omics technologies to study pulmonary physiology and pathology at the systems level.

Authors:  Ravi Ramesh Pathak; Vrushank Davé
Journal:  Cell Physiol Biochem       Date:  2014-04-28
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