BACKGROUND: To determine whether significant symptoms of inattention were present among the offspring of well-characterized bipolar parents. METHODS: We included 53 offspring of 30 parents meeting DSM-IV criteria for bipolar disorder diagnosed by consensus on the basis of a SADS-L interview and a wealth of longitudinal clinical data. The unaffected parent had no lifetime history of a major psychiatric illness. Offspring, prospectively followed for up to 5 years, completed psychometric measures of attention and mood when judged to be at a good level of functioning (well, remitted or treated). RESULTS: Those offspring with any lifetime psychiatric diagnosis endorsed more subjective problems with attention. However, there was no measurable difference on tasks of sustained attention between those with and those without a lifetime psychiatric illness including affective disorder. There was a significant association between self-reported symptoms of depression and inattention, but no association between either self-report measure and an objective measure of sustained attention. LIMITATIONS: This study was not intended to be a comprehensive neuropsychological investigation of at risk offspring. CONCLUSIONS: In this high-risk population, subjective difficulty with attention appeared to be state-dependent, associated with the degree of subjective distress related to an underlying psychiatric illness.
BACKGROUND: To determine whether significant symptoms of inattention were present among the offspring of well-characterized bipolar parents. METHODS: We included 53 offspring of 30 parents meeting DSM-IV criteria for bipolar disorder diagnosed by consensus on the basis of a SADS-L interview and a wealth of longitudinal clinical data. The unaffected parent had no lifetime history of a major psychiatric illness. Offspring, prospectively followed for up to 5 years, completed psychometric measures of attention and mood when judged to be at a good level of functioning (well, remitted or treated). RESULTS: Those offspring with any lifetime psychiatric diagnosis endorsed more subjective problems with attention. However, there was no measurable difference on tasks of sustained attention between those with and those without a lifetime psychiatric illness including affective disorder. There was a significant association between self-reported symptoms of depression and inattention, but no association between either self-report measure and an objective measure of sustained attention. LIMITATIONS: This study was not intended to be a comprehensive neuropsychological investigation of at risk offspring. CONCLUSIONS: In this high-risk population, subjective difficulty with attention appeared to be state-dependent, associated with the degree of subjective distress related to an underlying psychiatric illness.
Authors: Jae-Won Kim; Haifeng Yu; Neal D Ryan; David A Axelson; Benjamin I Goldstein; Tina R Goldstein; Rasim S Diler; Kelly Monk; Mary Beth Hickey; Dara J Sakolsky; John A Merranko; Boris Birmaher Journal: J Clin Psychiatry Date: 2015-05 Impact factor: 4.384
Authors: Dina R Hirshfeld-Becker; Joseph Biederman; Aude Henin; Stephen V Faraone; Jamie A Micco; Anne van Grondelle; Brianne Henry; Jerrold F Rosenbaum Journal: Biol Psychiatry Date: 2007-02-16 Impact factor: 13.382
Authors: Giacomo Salvadore; Wayne C Drevets; Ioline D Henter; Carlos A Zarate; Husseini K Manji Journal: Early Interv Psychiatry Date: 2008-08 Impact factor: 2.732
Authors: Manpreet K Singh; Melissa P DelBello; David E Fleck; Paula K Shear; Stephen M Strakowski Journal: J Clin Exp Neuropsychol Date: 2008-05-06 Impact factor: 2.475