BACKGROUND: Working memory deficits abound in schizophrenia and attention deficits have been documented in schizophrenia and bipolar disorder. Adolescent offspring of patients may inherit vulnerabilities in brain circuits that subserve these cognitive domains. Here we assess impairments in offspring of schizophrenia (SCZ-Offspring) or bipolar (BP-Offspring) patients compared to controls (HC) with no family history of mood or psychotic disorders to the second degree. METHODS: Three groups (n=100 subjects; range: 10-20 yrs) of HC, SCZ-Offspring and BP-Offspring gave informed consent. Working memory was assessed using a delayed spatial memory paradigm with two levels of delay (2s & 12s); sustained attention processing was assessed using the Continuous Performance Task-Identical Pairs version. RESULTS: SCZ-Offspring (but not BP-Offspring) showed impairments in working memory (relative to HC) at the longer memory delay indicating a unique deficit. Both groups showed reduced sensitivity during attention but only BP-Offspring significantly differed from controls. CONCLUSIONS: These results suggest unique (working memory/dorsal frontal cortex) and potentially overlapping (attention/fronto-striatal cortex) vulnerability pathways in adolescent offspring of patients with schizophrenia and bipolar disorder. Working memory and attention assessments in these offspring may assist in the clinical characterization of the adolescents vulnerable to SCZ or BP.
BACKGROUND:Working memory deficits abound in schizophrenia and attention deficits have been documented in schizophrenia and bipolar disorder. Adolescent offspring of patients may inherit vulnerabilities in brain circuits that subserve these cognitive domains. Here we assess impairments in offspring of schizophrenia (SCZ-Offspring) or bipolar (BP-Offspring) patients compared to controls (HC) with no family history of mood or psychotic disorders to the second degree. METHODS: Three groups (n=100 subjects; range: 10-20 yrs) of HC, SCZ-Offspring and BP-Offspring gave informed consent. Working memory was assessed using a delayed spatial memory paradigm with two levels of delay (2s & 12s); sustained attention processing was assessed using the Continuous Performance Task-Identical Pairs version. RESULTS:SCZ-Offspring (but not BP-Offspring) showed impairments in working memory (relative to HC) at the longer memory delay indicating a unique deficit. Both groups showed reduced sensitivity during attention but only BP-Offspring significantly differed from controls. CONCLUSIONS: These results suggest unique (working memory/dorsal frontal cortex) and potentially overlapping (attention/fronto-striatal cortex) vulnerability pathways in adolescent offspring of patients with schizophrenia and bipolar disorder. Working memory and attention assessments in these offspring may assist in the clinical characterization of the adolescents vulnerable to SCZ or BP.
Authors: K Rubia; S Overmeyer; E Taylor; M Brammer; S C Williams; A Simmons; C Andrew; E T Bullmore Journal: Neurosci Biobehav Rev Date: 2000-01 Impact factor: 8.989
Authors: Vaibhav A Diwadkar; Debra M Montrose; Diana Dworakowski; John A Sweeney; Matcheri S Keshavan Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2005-11-28 Impact factor: 5.067
Authors: Susheel Vijayraghavan; Min Wang; Shari G Birnbaum; Graham V Williams; Amy F T Arnsten Journal: Nat Neurosci Date: 2007-02-04 Impact factor: 24.884
Authors: Manon Hj Hillegers; Catrien G Reichart; Marjolein Wals; Frank C Verhulst; Johan Ormel; Willem A Nolen Journal: Bipolar Disord Date: 2005-08 Impact factor: 6.744
Authors: Isabelle E Bauer; Thomas W Frazier; Thomas D Meyer; Eric Youngstrom; Giovana B Zunta-Soares; Jair C Soares Journal: J Child Adolesc Psychopharmacol Date: 2015-10-15 Impact factor: 2.576
Authors: Christen M Deveney; Megan E Connolly; Sarah E Jenkins; Pilyoung Kim; Stephen J Fromm; Melissa A Brotman; Daniel S Pine; Ellen Leibenluft Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2012-03-04 Impact factor: 5.067
Authors: Luis R Patino; Caleb M Adler; Neil P Mills; Stephen M Strakowski; David E Fleck; Jeffrey A Welge; Melissa P DelBello Journal: Bipolar Disord Date: 2013-03-26 Impact factor: 6.744
Authors: Gisela Sugranyes; Elena de la Serna; Roger Borras; Vanessa Sanchez-Gistau; Jose C Pariente; Soledad Romero; Inmaculada Baeza; Covadonga M Díaz-Caneja; Elisa Rodriguez-Toscano; Carmen Moreno; Miguel Bernardo; Dolores Moreno; Eduard Vieta; Josefina Castro-Fornieles Journal: Schizophr Bull Date: 2017-10-21 Impact factor: 9.306
Authors: Katrina C Johnson; Patricia A Brennan; Zachary N Stowe; Ellen Leibenluft; D Jeffrey Newport Journal: J Child Psychol Psychiatry Date: 2013-08-28 Impact factor: 8.982