Literature DB >> 11861605

E protein function in lymphocyte development.

Melanie W Quong1, William J Romanow, Cornelis Murre.   

Abstract

Lymphocytes arise from hematopoietic stem cells through the coordinated action of transcription factors. The E proteins (E12, E47, HEB and E2-2) have emerged as key regulators of both B and T lymphocyte differentiation. This review summarizes the current data and examines the various functions of E proteins and their antagonists, Id2 and Id3, throughout lymphoid maturation. Beyond an established role in B and T lineage commitment, E proteins continue to be essential at subsequent stages of development. E protein activity regulates the expression of surrogate and antigen receptor genes, promotes Ig and TCR rearrangements, and coordinates cell survival and proliferation with developmental progression in response to TCR signaling. Finally, this review also discusses the role of E47 as a tumor suppressor.

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Year:  2001        PMID： 11861605     DOI： 10.1146/annurev.immunol.20.092501.162048

Source DB:  PubMed          Journal:  Annu Rev Immunol        ISSN： 0732-0582            Impact factor:   28.527


  63 in total

1.  Cutting Edge: Dynamic Expression of Id3 Defines the Stepwise Differentiation of Tissue-Resident Regulatory T Cells.

Authors:  Jenna M Sullivan; Barbara Höllbacher; Daniel J Campbell
Journal:  J Immunol       Date:  2018-12-05       Impact factor: 5.422

Review 2.  Transcriptional control of thymocyte positive selection.

Authors:  Gilbert J Kersh
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

3.  The E47 transcription factor negatively regulates CD5 expression during thymocyte development.

Authors:  Yang Yang; Christopher H Contag; Dean Felsher; Catherine M Shachaf; Yuan Cao; Leonard A Herzenberg; Leonore A Herzenberg; James W Tung
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-04       Impact factor: 11.205

4.  A promoter polymorphism in the central MHC gene, IKBL, influences the binding of transcription factors USF1 and E47 on disease-associated haplotypes.

Authors:  Alvin Boodhoo; Agnes M L Wong; David Williamson; Dominic Voon; Silvia Lee; Richard J N Allcock; Patricia Price
Journal:  Gene Expr       Date:  2004

5.  Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.

Authors:  Jun-Ho Lee; Shengli Zhou; Cynthia M Smas
Journal:  J Cell Biochem       Date:  2010-09-01       Impact factor: 4.429

Review 6.  Age effects on B cells and humoral immunity in humans.

Authors:  Daniela Frasca; Alain Diaz; Maria Romero; Ana Marie Landin; Bonnie B Blomberg
Journal:  Ageing Res Rev       Date:  2010-08-20       Impact factor: 10.895

Review 7.  Aging, cytomegalovirus (CMV) and influenza vaccine responses.

Authors:  Daniela Frasca; Bonnie B Blomberg
Journal:  Hum Vaccin Immunother       Date:  2016-03-03       Impact factor: 3.452

8.  Antibody repertoire development in fetal and neonatal piglets. XI. The thymic B-cell repertoire develops independently from that in blood and mesenteric lymph nodes.

Authors:  Jeremy McAleer; Patrick Weber; Jishan Sun; John E Butler
Journal:  Immunology       Date:  2005-02       Impact factor: 7.397

9.  IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.

Authors:  Kazu Kikuchi; Hirotake Kasai; Akiko Watanabe; Anne Y Lai; Motonari Kondo
Journal:  J Immunol       Date:  2008-07-01       Impact factor: 5.422

Review 10.  Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.

Authors:  Shane Crotty; Robert J Johnston; Stephen P Schoenberger
Journal:  Nat Immunol       Date:  2010-01-19       Impact factor: 25.606
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