Literature DB >> 11858998

Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.

Atul Goel1, Sharlyn J Mazur, Rasem J Fattah, Tracy L Hartman, Jim A Turpin, Mingjun Huang, William G Rice, Ettore Appella, John K Inman.   

Abstract

The HIV-1 nucleocapsid protein NCp7, which contains two highly conserved zinc fingers, is being used as a novel target for AIDS therapy due to its pivotal role in viral replication and its mutationally intolerant nature. Herein we report a new class of NCp7 inhibitors that possess good antiviral activity with low cellular toxicity.

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Year:  2002        PMID： 11858998     DOI： 10.1016/s0960-894x(02)00007-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  A one-pot preparation of N-2-mercaptobenzoyl-amino amides.

Authors:  Robert J Bahde; Daniel H Appella; William C Trenkle
Journal:  Tetrahedron Lett       Date:  2011-08-10       Impact factor: 2.415

2.  Novel and efficient one-pot five- and six-component reactions for the stereoselective synthesis of highly functionalized enaminones and dithiocarbamates.

Authors:  Morteza Bararjanian; Saeed Balalaie; Frank Rominger; Barahman Movassagh; Hamid Reza Bijanzadeh
Journal:  Mol Divers       Date:  2010-11-12       Impact factor: 2.943

Review 3.  Nucleocapsid protein function in early infection processes.

Authors:  James A Thomas; Robert J Gorelick
Journal:  Virus Res       Date:  2008-02-14       Impact factor: 3.303

Review 4.  HIV type 1 Gag as a target for antiviral therapy.

Authors:  Abdul A Waheed; Eric O Freed
Journal:  AIDS Res Hum Retroviruses       Date:  2011-09-21       Impact factor: 2.205

5.  Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity.

Authors:  Weiming Luo; Qian-sheng Yu; Isidro Salcedo; Harold W Holloway; Debomoy K Lahiri; Arnold Brossi; David Tweedie; Nigel H Greig
Journal:  Bioorg Med Chem       Date:  2011-05-23       Impact factor: 3.641

Review 6.  Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy.

Authors:  Divita Garg; Bruce E Torbett
Journal:  Virus Res       Date:  2014-07-12       Impact factor: 3.303

Review 7.  HIV-1 gag: an emerging target for antiretroviral therapy.

Authors:  Philip R Tedbury; Eric O Freed
Journal:  Curr Top Microbiol Immunol       Date:  2015       Impact factor: 4.291

8.  Anisotropic, Polarizable Molecular Mechanics Studies of Inter- and Intramolecular Interactions and Ligand-Macromolecule Complexes. A Bottom-Up Strategy.

Authors:  Nohad Gresh; G Andrés Cisneros; Thomas A Darden; Jean-Philip Piquemal
Journal:  J Chem Theory Comput       Date:  2007-11       Impact factor: 6.006

9.  Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides.

Authors:  A Robert Neurath; Nathan Strick; Yun-Yao Li
Journal:  BMC Infect Dis       Date:  2006-10-16       Impact factor: 3.090

10.  Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein.

Authors:  Min-Jung Kim; Seon Hee Kim; Jung Ae Park; Kyung Lee Yu; Soo In Jang; Byung Soo Kim; Eun Soo Lee; Ji Chang You
Journal:  Retrovirology       Date:  2015-11-06       Impact factor: 4.602
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