Literature DB >> 11849947

Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins.

D J Segal1, C F Barbas.   

Abstract

Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

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Year:  2001        PMID： 11849947     DOI： 10.1016/s0958-1669(01)00272-5

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  31 in total

Review 1.  Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.

Authors:  Taco G Uil; Hidde J Haisma; Marianne G Rots
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

2.  Toward a functional annotation of the human genome using artificial transcription factors.

Authors:  Dong-ki Lee; Jin Woo Park; Youn-Jae Kim; Jiwon Kim; Yangsoon Lee; Jeonglim Kim; Jin-Soo Kim
Journal:  Genome Res       Date:  2003-12       Impact factor: 9.043

3.  Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection.

Authors:  Jessica A Hurt; Stacey A Thibodeau; Andrew S Hirsh; Carl O Pabo; J Keith Joung
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-03       Impact factor: 11.205

4.  Regulation of transgene expression in plants with polydactyl zinc finger transcription factors.

Authors:  M Isabel Ordiz; Carlos F Barbas; Roger N Beachy
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-23       Impact factor: 11.205

5.  Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble.

Authors:  Levani Zandarashvili; Alexandre Esadze; Dana Vuzman; Catherine A Kemme; Yaakov Levy; Junji Iwahara
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-31       Impact factor: 11.205

Review 6.  Laboratory-directed protein evolution.

Authors:  Ling Yuan; Itzhak Kurek; James English; Robert Keenan
Journal:  Microbiol Mol Biol Rev       Date:  2005-09       Impact factor: 11.056

7.  Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA.

Authors:  Aik T Ooi; Cliff I Stains; Indraneel Ghosh; David J Segal
Journal:  Biochemistry       Date:  2006-03-21       Impact factor: 3.162

8.  The prospects for designer single-stranded RNA-binding proteins.

Authors:  Joel P Mackay; Josep Font; David J Segal
Journal:  Nat Struct Mol Biol       Date:  2011-02-27       Impact factor: 15.369

9.  Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker.

Authors:  Yuka Shimizu; Mital S Bhakta; David J Segal
Journal:  Bioorg Med Chem Lett       Date:  2009-03-03       Impact factor: 2.823

Review 10.  Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics.

Authors:  Fyodor D Urnov; Edward J Rebar; Andreas Reik; Pier Paolo Pandolfi
Journal:  EMBO Rep       Date:  2002-07       Impact factor: 8.807
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