| Literature DB >> 11846838 |
B J Tura1, K E Bunyan, D J Harrison.
Abstract
The inflammatory cytokine interferon gamma (IFNgamma) can cause cell cycle arrest and apoptosis in the hepatocyte. Primarily these processes are protective but in chronic liver disease oncogenic mutations may prosper. IFNgamma signalling is discussed showing how p53 is induced to cause cell cycle arrest. While caspases are are known to be responsible for IFNgamma induced apoptosis, how they are activated is unclear. Potential mechanisms are reviewed.Entities:
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Year: 2001 PMID： 11846838 PMCID： PMC2517788 DOI： 10.1046/j.1365-2613.2001.00207.x
Source DB: PubMed Journal: Int J Exp Pathol ISSN： 0959-9673 Impact factor: 1.925