Literature DB >> 3409321

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements.

M Miyamoto1, T Fujita, Y Kimura, M Maruyama, H Harada, Y Sudo, T Miyata, T Taniguchi.   

Abstract

Expression of the interferon-beta (IFN-beta) gene is induced by a variety of agents, including viruses. Evidence has been provided that a mouse nuclear factor, termed interferon regulatory factor-1 (IRF-1), specifically binds to the upstream regulatory region of the human IFN-beta gene and mediates virus-induced transcription of the gene. In this study, we describe the molecular cloning and characterization of the mouse and human cDNAs encoding IRF-1. Our results suggest that IRF-1 is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes. Surprisingly, IRF-1 gene expression is dramatically induced by Newcastle disease virus in mouse L929 cells and by Concanavalin A in spleen cells. We show here that the IRF-1 gene possesses virus-inducible promoter.

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Year:  1988        PMID： 3409321     DOI： 10.1016/s0092-8674(88)91307-4

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  308 in total

1.  DNA binding and transcription activation by chicken interferon regulatory factor-3 (chIRF-3).

Authors:  C E Grant; D L May; R G Deeley
Journal:  Nucleic Acids Res       Date:  2000-12-01       Impact factor: 16.971

2.  Biologic consequences of Stat1-independent IFN signaling.

Authors:  M P Gil; E Bohn; A K O'Guin; C V Ramana; B Levine; G R Stark; H W Virgin; R D Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-05       Impact factor: 11.205

3.  A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein.

Authors:  Jirí Nehyba; Radmila Hrdlicková; Joan Burnside; Henry R Bose
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

4.  Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.

Authors:  C Van Lint; C A Amella; S Emiliani; M John; T Jie; E Verdin
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

5.  Altered immune response of interferon regulatory factor 1-deficient mice against Plasmodium berghei blood-stage malaria infection.

Authors:  R S Tan; C Feng; Y Asano; A U Kara
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

6.  Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.

Authors:  R Lin; P Génin; Y Mamane; J Hiscott
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

7.  Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.

Authors:  Xin M Luo; A Catharine Ross
Journal:  Exp Biol Med (Maywood)       Date:  2006-05

8.  Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Authors:  T Fujita; L F Reis; N Watanabe; Y Kimura; T Taniguchi; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

9.  Gene cloning and expression analysis of IRF1 in half-smooth tongue sole (Cynoglossus semilaevis).

Authors:  Yang Lu; Qilong Wang; Yang Liu; Changwei Shao; Songlin Chen; Zhenxia Sha
Journal:  Mol Biol Rep       Date:  2014-03-01       Impact factor: 2.316

10.  Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.

Authors:  E Garoufalis; I Kwan; R Lin; A Mustafa; N Pepin; A Roulston; J Lacoste; J Hiscott
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103
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