Literature DB >> 2475256

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

H Harada1, T Fujita, M Miyamoto, Y Kimura, M Maruyama, A Furia, T Miyata, T Taniguchi.   

Abstract

Viral infections commonly induce expression of type I interferon (IFN) genes. The induction is transient and involves transcriptional activation wherein a positive factor, IRF-1, binds to upstream regulatory cis elements. In the present study we report the isolation of a cDNA encoding a novel factor, termed IRF-2, that interacts with the same nucleotide sequence elements as IRF-1. Both genes are inducible not only by virus but also by IFN. Unlike IRF-1, IRF-2 does not function as an activator; rather, it suppresses the function of IRF-1 under certain circumstances. Our results suggest that transcription of the IFN and IFN-inducible genes is regulated by two similar trans-acting factors that apparently compete for the same cis-acting recognition sequences, but which have opposite effects.

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Year:  1989        PMID： 2475256     DOI： 10.1016/0092-8674(89)90107-4

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  285 in total

1.  Interferon regulatory factor 2 represses the Epstein-Barr virus BamHI Q latency promoter in type III latency.

Authors:  L Zhang; J S Pagano
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

2.  DNA binding and transcription activation by chicken interferon regulatory factor-3 (chIRF-3).

Authors:  C E Grant; D L May; R G Deeley
Journal:  Nucleic Acids Res       Date:  2000-12-01       Impact factor: 16.971

3.  A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein.

Authors:  Jirí Nehyba; Radmila Hrdlicková; Joan Burnside; Henry R Bose
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

4.  Repression of virus-induced interferon A promoters by homeodomain transcription factor Ptx1.

Authors:  S Lopez; M L Island; J Drouin; M T Bandu; N Christeff; N Darracq; R Barbey; J Doly; D Thomas; S Navarro
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

5.  Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors.

Authors:  B Lubyova; P M Pitha
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

6.  Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.

Authors:  C Van Lint; C A Amella; S Emiliani; M John; T Jie; E Verdin
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

7.  Altered immune response of interferon regulatory factor 1-deficient mice against Plasmodium berghei blood-stage malaria infection.

Authors:  R S Tan; C Feng; Y Asano; A U Kara
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

8.  Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.

Authors:  R Lin; P Génin; Y Mamane; J Hiscott
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

9.  Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Authors:  T Fujita; L F Reis; N Watanabe; Y Kimura; T Taniguchi; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

10.  Gene cloning and expression analysis of IRF1 in half-smooth tongue sole (Cynoglossus semilaevis).

Authors:  Yang Lu; Qilong Wang; Yang Liu; Changwei Shao; Songlin Chen; Zhenxia Sha
Journal:  Mol Biol Rep       Date:  2014-03-01       Impact factor: 2.316
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