STUDY OBJECTIVES: The purpose of this study was to determine the impact of a pretransplantation determination of body mass index (BMI) on survival after lung transplantation. DESIGN AND PATIENTS: Univariate and multivariate survival analyses of a single institution database consisting of 85 patients who had undergone lung transplantations between March 1994 and October 1998. SETTING: University of Florida Health Science Center. RESULTS: Kaplan-Meier survival curves showed that patients who were obese (ie, BMI, > or = 30) at a pretransplantation assessment had a marked decrease in posttransplantation survival time (log rank, p < 0.05; Wilcoxon, p < 0.05). The final Cox regression model revealed that the most powerful predictors of mortality after lung transplantation were higher pretransplantation BMI and the development of obliterative bronchiolitis. CONCLUSIONS: Our results suggest that the posttransplantation risk for mortality is possibly three times greater for obese patients than for nonobese patients. Additional study is needed to identify the mechanisms for such higher risk in obese patients. Our data also suggest that transplantation centers should not routinely reject underweight patients (ie, BMI, < 18.5) or overweight patients (ie, BMI, 25 to 29.9) for lung transplantation listing solely on the basis of weight, as their outcomes may not be significantly different than patients with normal BMIs.
STUDY OBJECTIVES: The purpose of this study was to determine the impact of a pretransplantation determination of body mass index (BMI) on survival after lung transplantation. DESIGN AND PATIENTS: Univariate and multivariate survival analyses of a single institution database consisting of 85 patients who had undergone lung transplantations between March 1994 and October 1998. SETTING: University of Florida Health Science Center. RESULTS: Kaplan-Meier survival curves showed that patients who were obese (ie, BMI, > or = 30) at a pretransplantation assessment had a marked decrease in posttransplantation survival time (log rank, p < 0.05; Wilcoxon, p < 0.05). The final Cox regression model revealed that the most powerful predictors of mortality after lung transplantation were higher pretransplantation BMI and the development of obliterative bronchiolitis. CONCLUSIONS: Our results suggest that the posttransplantation risk for mortality is possibly three times greater for obesepatients than for nonobese patients. Additional study is needed to identify the mechanisms for such higher risk in obesepatients. Our data also suggest that transplantation centers should not routinely reject underweight patients (ie, BMI, < 18.5) or overweight patients (ie, BMI, 25 to 29.9) for lung transplantation listing solely on the basis of weight, as their outcomes may not be significantly different than patients with normal BMIs.
Authors: Jonathan P Singer; Eric R Peterson; Mark E Snyder; Patricia P Katz; Jeffrey A Golden; Frank D'Ovidio; Matthew Bacchetta; Joshua R Sonett; Jasleen Kukreja; Lori Shah; Hilary Robbins; Kristin Van Horn; Rupal J Shah; Joshua M Diamond; Nancy Wickersham; Li Sun; Steven Hays; Selim M Arcasoy; Scott M Palmer; Lorraine B Ware; Jason D Christie; David J Lederer Journal: Am J Respir Crit Care Med Date: 2014-11-01 Impact factor: 21.405
Authors: David J Lederer; Steven M Kawut; Nancy Wickersham; Christopher Winterbottom; Sangeeta Bhorade; Scott M Palmer; James Lee; Joshua M Diamond; Keith M Wille; Ann Weinacker; Vibha N Lama; Maria Crespo; Jonathan B Orens; Joshua R Sonett; Selim M Arcasoy; Lorraine B Ware; Jason D Christie Journal: Am J Respir Crit Care Med Date: 2011-11-01 Impact factor: 21.405
Authors: Satish Chandrashekaran; Cesar A Keller; Walter K Kremers; Steve G Peters; Matthew A Hathcock; Cassie C Kennedy Journal: J Heart Lung Transplant Date: 2014-11-17 Impact factor: 10.247
Authors: David J Lederer; Jessie S Wilt; Frank D'Ovidio; Matthew D Bacchetta; Lori Shah; Shankari Ravichandran; Jenny Lenoir; Brenda Klein; Joshua R Sonett; Selim M Arcasoy Journal: Am J Respir Crit Care Med Date: 2009-07-16 Impact factor: 21.405
Authors: Ramiro Fernandez; Niloufar Safaeinili; Chitaru Kurihara; David D Odell; Manu Jain; Malcolm M DeCamp; G R Scott Budinger; Ankit Bharat Journal: J Thorac Cardiovasc Surg Date: 2017-11-20 Impact factor: 5.209
Authors: Emily Siu Clausen; Courtney Frankel; Scott M Palmer; Laurie D Snyder; Patrick J Smith Journal: J Heart Lung Transplant Date: 2018-07-29 Impact factor: 10.247