OBJECTIVE: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD. METHOD: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 AD patients and 28 age- and sex-matched healthy control subjects. RESULTS: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD. CONCLUSION: Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.
OBJECTIVE: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD. METHOD: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 ADpatients and 28 age- and sex-matched healthy control subjects. RESULTS: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD. CONCLUSION:Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.
Authors: Arijitt Borthakur; Matthew Sochor; Christos Davatzikos; John Q Trojanowski; Christopher M Clark Journal: Neuroimage Date: 2008-04-01 Impact factor: 6.556
Authors: Christine Fennema-Notestine; Linda K McEvoy; Donald J Hagler; Mark W Jacobson; Anders M Dale Journal: Behav Neurol Date: 2009 Impact factor: 3.342
Authors: Eva M Meisenzahl; Doerthe Seifert; Ronald Bottlender; Stefan Teipel; Thomas Zetzsche; Markus Jäger; Nikolaos Koutsouleris; Gisela Schmitt; Johanna Scheuerecker; Bernhard Burgermeister; Harald Hampel; Tobias Rupprecht; Christine Born; Maximilian Reiser; Hans-Jürgen Möller; Thomas Frodl Journal: Eur Arch Psychiatry Clin Neurosci Date: 2009-06-03 Impact factor: 5.270