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Literature DB >> 1180546

Concentration of clindamycin in human bone.

P Nicholas, B R Meyers, R N Levy, S Z Hirschman.

Abstract

Thirty patients undergoing total hip replacement received clindamycin beginning the day before surgery. Mean clindamycin concentrations during surgery were 7.33 +/- 3.37 mug/ml in serum and 2.63 +/- 1.76 mug/g in bone; mean ratio of bone-serum concentration was 0.40 +/- 0.30.

Entities: Chemical Species

Mesh：

Substances：
Clindamycin

Year: 1975 PMID： 1180546 PMCID： PMC429291 DOI： 10.1128/AAC.8.2.220

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

3 in total

1. Arthroplasty of the hip. A new operation.

Authors: J Charnley
Journal: Lancet Date: 1961-05-27 Impact factor: 79.321

2. Antibiotic concentrations in human bone. A preliminary report.

Authors: M C Kolczun; C L Nelson; M C McHenry; T L Gavan; P Pinovich
Journal: J Bone Joint Surg Am Date: 1974-03 Impact factor: 5.284

3. Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone.

Authors: C W Norden
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

3 in total

14 in total

1. Pharmacokinetic variability of clindamycin and influence of rifampicin on clindamycin concentration in patients with bone and joint infections.

Authors: Emmanuel Curis; Vincent Pestre; Vincent Jullien; Luc Eyrolle; Denis Archambeau; Philippe Morand; Laure Gatin; Matthieu Karoubi; Nicolas Pinar; Valérie Dumaine; Jean-Claude Nguyen Van; Antoine Babinet; Philippe Anract; Dominique Salmon
Journal: Infection Date: 2015-04-03 Impact factor: 3.553

2. Osteomyelitis management: More art than science?

Authors: Bl Johnston; Jm Conly
Journal: Can J Infect Dis Med Microbiol Date: 2007-03 Impact factor: 2.471

3. Extended-duration dosing and distribution of dalbavancin into bone and articular tissue.

Authors: Michael W Dunne; Sailaja Puttagunta; Craig R Sprenger; Chris Rubino; Scott Van Wart; James Baldassarre
Journal: Antimicrob Agents Chemother Date: 2015-01-05 Impact factor: 5.191

4. Tissue concentrations of third-generation cephalosporins (ceftazidime and ceftriaxone) in lower extremity tissues using a tourniquet.

Authors: N Papaioannou; L Kalivas; J Kalavritinos; S Tsourvakas
Journal: Arch Orthop Trauma Surg Date: 1994 Impact factor: 3.067

Concentration of clindamycin in human bone.

1. Arthroplasty of the hip. A new operation.

2. Antibiotic concentrations in human bone. A preliminary report.

3. Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone.

1. Pharmacokinetic variability of clindamycin and influence of rifampicin on clindamycin concentration in patients with bone and joint infections.

2. Osteomyelitis management: More art than science?

3. Extended-duration dosing and distribution of dalbavancin into bone and articular tissue.

4. Tissue concentrations of third-generation cephalosporins (ceftazidime and ceftriaxone) in lower extremity tissues using a tourniquet.

5. Penetration of methicillin, oxacillin, and cephalothin into bone and synovial tissues.

Review 6. Systemic antibiotic therapy for chronic osteomyelitis in adults.

7. Antibiotic penetration into rabbit nucleus pulposus with discitis.

Review 8. Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations.

9. [Bone concentration of a new antimicrobial agent azlocillin (author's transl)].

10. Concentrations of amoxicillin and clindamycin in teeth following a single dose of oral medication.