Literature DB >> 11801452

Mechanism and control of class-switch recombination.

John P Manis1, Ming Tian, Frederick W Alt.   

Abstract

Class-switch recombination (CSR) occurs by an unusual and intriguing mechanism that has not been clearly elucidated as yet. Currently, we know that this mechanism involves recombination between large and highly repetitive switch (S) regions, is targeted by S-region transcription and requires the activity of the newly discovered activation-induced deaminase (AID). In this review, we discuss the potential role of these factors in CSR, discuss potential relationships between CSR and somatic hypermutation, and speculate how CSR and related mechanisms might contribute to genomic instability.

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Year:  2002        PMID： 11801452     DOI： 10.1016/s1471-4906(01)02111-1

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  122 in total

Review 1.  Unravelling the web of DNA repair disorders.

Authors:  A R Gennery; M O'Driscoll
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2.  DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.

Authors:  Mikhail B Litinskiy; Bernardetta Nardelli; David M Hilbert; Bing He; Andras Schaffer; Paolo Casali; Andrea Cerutti
Journal:  Nat Immunol       Date:  2002-08-05       Impact factor: 25.606

3.  The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination.

Authors:  Edmund C Kim; Christopher R Edmonston; Xiaoping Wu; András Schaffer; Paolo Casali
Journal:  J Biol Chem       Date:  2004-07-13       Impact factor: 5.157

Review 4.  The role of regulatory T cells in allergy.

Authors:  Maria A Curotto de Lafaille; Juan J Lafaille
Journal:  Springer Semin Immunopathol       Date:  2003-10-22

5.  Impaired IgA class switching in APRIL-deficient mice.

Authors:  Emanuela Castigli; Sumi Scott; Fatma Dedeoglu; Paul Bryce; Haifa Jabara; Atul K Bhan; Emiko Mizoguchi; Raif S Geha
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-26       Impact factor: 11.205

Review 6.  Roles of the NF-kappaB pathway in lymphocyte development and function.

Authors:  Steve Gerondakis; Ulrich Siebenlist
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-12-23       Impact factor: 10.005

Review 7.  Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.

Authors:  Bao Q Vuong; Jayanta Chaudhuri
Journal:  Semin Immunol       Date:  2012-07-06       Impact factor: 11.130

8.  Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers.

Authors:  Bettina Budeus; Stefanie Schweigle de Reynoso; Martina Przekopowitz; Daniel Hoffmann; Marc Seifert; Ralf Küppers
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-31       Impact factor: 11.205

9.  S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

Authors:  Robert Wuerffel; Lili Wang; Fernando Grigera; John Manis; Erik Selsing; Thomas Perlot; Frederick W Alt; Michel Cogne; Eric Pinaud; Amy L Kenter
Journal:  Immunity       Date:  2007-11-01       Impact factor: 31.745

Review 10.  Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection.

Authors:  Zdenek Hel; Elizabeth Stringer; Jiri Mestecky
Journal:  Endocr Rev       Date:  2009-11-10       Impact factor: 19.871
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