Literature DB >> 14513375

Miltefosine (Impavido): the first oral treatment against leishmaniasis.

H Sindermann1, S L Croft, K R Engel, W Bommer, H J Eibl, C Unger, J Engel.   

Abstract

Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advantage of oral administration over the currently recommended antileishmanial drugs that require parenteral administration. Miltefosine produces high cure rates also in patients resistant to the standard antimonial therapy.

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Year:  2003        PMID: 14513375     DOI: 10.1007/s00430-003-0201-2

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN: 0300-8584            Impact factor:   3.402


  52 in total

1.  Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice.

Authors:  P Escobar; V Yardley; S L Croft
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

2.  Influence of hexadecylphosphocholine (miltefosine) on cytokine synthesis and biological responses.

Authors:  T Klenner; T Beckers; K Nooter; H Holtmann
Journal:  Adv Exp Med Biol       Date:  1996       Impact factor: 2.622

3.  Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani.

Authors:  R Lira; S Sundar; A Makharia; R Kenney; A Gam; E Saraiva; D Sacks
Journal:  J Infect Dis       Date:  1999-08       Impact factor: 5.226

4.  Visceral leishmaniasis following treatment with liposomal amphotericin B.

Authors:  M McBride; M Linney; E J Claydon; J Weber
Journal:  Clin Infect Dis       Date:  1994-08       Impact factor: 9.079

5.  Short- and long-term efficacy of hexadecylphosphocholine against established Leishmania infantum infection in BALB/c mice.

Authors:  Y Le Fichoux; D Rousseau; B Ferrua; S Ruette; A Lelièvre; D Grousson; J Kubar
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

6.  Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania.

Authors:  H Lux; N Heise; T Klenner; D Hart; F R Opperdoes
Journal:  Mol Biochem Parasitol       Date:  2000-11       Impact factor: 1.759

7.  Aminosidine and its combination with sodium stibogluconate in the treatment of diffuse cutaneous leishmaniasis caused by Leishmania aethiopica.

Authors:  S Teklemariam; A G Hiwot; D Frommel; T L Miko; G Ganlov; A Bryceson
Journal:  Trans R Soc Trop Med Hyg       Date:  1994 May-Jun       Impact factor: 2.184

8.  Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial.

Authors:  R N Davidson; L Di Martino; L Gradoni; R Giacchino; R Russo; G B Gaeta; R Pempinello; S Scott; F Raimondi; A Cascio
Journal:  Q J Med       Date:  1994-02

9.  Metabolism of ether lysophospholipids in Leishmania donovani promastigotes.

Authors:  V Achterberg; G Gercken
Journal:  Mol Biochem Parasitol       Date:  1987-12       Impact factor: 1.759

10.  Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotes.

Authors:  V Achterberg; G Gercken
Journal:  Mol Biochem Parasitol       Date:  1987-03       Impact factor: 1.759

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  16 in total

1.  Simple and efficient synthesis of 5'-aryl-5'-deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activities.

Authors:  Pierre Daligaux; Sébastien Pomel; Karine Leblanc; Philippe M Loiseau; Christian Cavé
Journal:  Mol Divers       Date:  2016-01-11       Impact factor: 2.943

2.  Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.

Authors:  Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 3.  Phospholipid and sphingolipid metabolism in Leishmania.

Authors:  Kai Zhang; Stephen M Beverley
Journal:  Mol Biochem Parasitol       Date:  2009-12-23       Impact factor: 1.759

4.  Ultrastructural analysis of miltefosine-induced surface membrane damage in adult Schistosoma mansoni BH strain worms.

Authors:  Humberto Gonçalves Bertão; Renata Alexandre Ramos da Silva; Rafael José R Padilha; Mônica Camelo Pessôa de Azevedo Albuquerque; Gandhi Rádis-Baptista
Journal:  Parasitol Res       Date:  2012-01-04       Impact factor: 2.289

5.  In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.

Authors:  Zhongsheng Tong; Fred Widmer; Tania C Sorrell; Zofia Guse; Katrina A Jolliffe; Catriona Halliday; Ok Cha Lee; Fanrong Kong; Lesley C Wright; Sharon C A Chen
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

6.  Miltefosine efficiently eliminates Leishmania major amastigotes from infected murine dendritic cells without altering their immune functions.

Authors:  Klaus Griewank; Caroline Gazeau; Andreas Eichhorn; Esther von Stebut
Journal:  Antimicrob Agents Chemother       Date:  2009-12-07       Impact factor: 5.191

7.  Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.

Authors:  Juan Román Luque-Ortega; Luis Rivas
Journal:  Antimicrob Agents Chemother       Date:  2007-02-05       Impact factor: 5.191

8.  In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.

Authors:  Juliany Cola Fernandes Rodrigues; Juan Luis Concepcion; Carlos Rodrigues; Aura Caldera; Julio A Urbina; Wanderley de Souza
Journal:  Antimicrob Agents Chemother       Date:  2008-09-02       Impact factor: 5.191

9.  Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis.

Authors:  Sara Teixeira de Macedo-Silva; Thais Larissa Araújo de Oliveira Silva; Julio A Urbina; Wanderley de Souza; Juliany Cola Fernandes Rodrigues
Journal:  Mol Biol Int       Date:  2011-06-13

10.  A Pilot Randomized Clinical Trial: Oral Miltefosine and Pentavalent Antimonials Associated With Pentoxifylline for the Treatment of American Tegumentary Leishmaniasis.

Authors:  Sofia Sales Martins; Daniel Holanda Barroso; Bruna Côrtes Rodrigues; Jorgeth de Oliveira Carneiro da Motta; Gustavo Subtil Magalhães Freire; Ledice Inácia de Araújo Pereira; Patrícia Shu Kurisky; Ciro Martins Gomes; Raimunda Nonata Ribeiro Sampaio
Journal:  Front Cell Infect Microbiol       Date:  2021-07-01       Impact factor: 5.293

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