Literature DB >> 11779820

Meiotic alterations in CAG repeat tracts.

J K Schweitzer1, S S Reinke, D M Livingston.   

Abstract

We have investigated meiotic changes in CAG repeat tracts embedded in a yeast chromosome. Repeat tracts undergo either conversion events between homologs or expansion and contraction events that appear to be confined to a single chromatid. We did not find evidence for conversion of tract interruptions or excess exchange of flanking markers.

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Year:  2001        PMID: 11779820      PMCID: PMC1461891     

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  15 in total

1.  Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis.

Authors:  H Cohen; D D Sears; D Zenvirth; P Hieter; G Simchen
Journal:  Mol Cell Biol       Date:  1999-06       Impact factor: 4.272

2.  Expansion and length-dependent fragility of CTG repeats in yeast.

Authors:  C H Freudenreich; S M Kantrow; V A Zakian
Journal:  Science       Date:  1998-02-06       Impact factor: 47.728

3.  The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast.

Authors:  M J Ireland; S S Reinke; D M Livingston
Journal:  Genetics       Date:  2000-08       Impact factor: 4.562

4.  Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome.

Authors:  C H Freudenreich; J B Stavenhagen; V A Zakian
Journal:  Mol Cell Biol       Date:  1997-04       Impact factor: 4.272

5.  Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae.

Authors:  D J Maurer; B L O'Callaghan; D M Livingston
Journal:  Mol Cell Biol       Date:  1996-12       Impact factor: 4.272

6.  Triplet repeats form secondary structures that escape DNA repair in yeast.

Authors:  H Moore; P W Greenwell; C P Liu; N Arnheim; T D Petes
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

7.  Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I.

Authors:  M Y Chung; L P Ranum; L A Duvick; A Servadio; H Y Zoghbi; H T Orr
Journal:  Nat Genet       Date:  1993-11       Impact factor: 38.330

Review 8.  Trinucleotide repeats in neurogenetic disorders.

Authors:  H L Paulson; K H Fischbeck
Journal:  Annu Rev Neurosci       Date:  1996       Impact factor: 12.449

9.  Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae.

Authors:  J J Miret; L Pessoa-Brandão; R S Lahue
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

10.  Mapping the polarity of changes that occur in interrupted CAG repeat tracts in yeast.

Authors:  D J Maurer; B L O'Callaghan; D M Livingston
Journal:  Mol Cell Biol       Date:  1998-08       Impact factor: 4.272

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  8 in total

1.  Genetic instability induced by overexpression of DNA ligase I in budding yeast.

Authors:  Jaichandar Subramanian; Sangeetha Vijayakumar; Alan E Tomkinson; Norman Arnheim
Journal:  Genetics       Date:  2005-06-18       Impact factor: 4.562

Review 2.  Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.

Authors:  Guy-Franck Richard; Alix Kerrest; Bernard Dujon
Journal:  Microbiol Mol Biol Rev       Date:  2008-12       Impact factor: 11.056

Review 3.  Repeat instability during DNA repair: Insights from model systems.

Authors:  Karen Usdin; Nealia C M House; Catherine H Freudenreich
Journal:  Crit Rev Biochem Mol Biol       Date:  2015-01-22       Impact factor: 8.250

Review 4.  On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.

Authors:  Alexandra N Khristich; Sergei M Mirkin
Journal:  J Biol Chem       Date:  2020-02-14       Impact factor: 5.157

5.  Both CAG repeats and inverted DNA repeats stimulate spontaneous unequal sister-chromatid exchange in Saccharomyces cerevisiae.

Authors:  Dilip K Nag; Manisha Suri; Erin K Stenson
Journal:  Nucleic Acids Res       Date:  2004-10-19       Impact factor: 16.971

Review 6.  Role of recombination and replication fork restart in repeat instability.

Authors:  Erica J Polleys; Nealia C M House; Catherine H Freudenreich
Journal:  DNA Repair (Amst)       Date:  2017-06-09

7.  Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.

Authors:  Julie L Callahan; Kenneth J Andrews; Virginia A Zakian; Catherine H Freudenreich
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

8.  Huntington disease expansion mutations in humans can occur before meiosis is completed.

Authors:  Song-Ro Yoon; Louis Dubeau; Margot de Young; Nancy S Wexler; Norman Arnheim
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-11       Impact factor: 11.205

  8 in total

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