Literature DB >> 11751633

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.

J D Reimann1, B E Gardner, F Margottin-Goguet, P K Jackson.   

Abstract

The anaphase-promoting complex/cyclosome (APC) ubiquitin ligase is activated by Cdc20 and Cdh1 and inhibited by Mad2 and the spindle assembly checkpoint complex, Mad2B, and the early mitotic inhibitor Emi1. Mad2 inhibits APC(Cdc20), whereas Mad2B preferentially inhibits APC(Cdh1). We have examined the mechanism of APC inhibition by Emi1 and find that unlike Mad2 proteins, Emi1 binds and inhibits both APC(Cdh1) and APC(Cdc20). Also unlike Mad2, Emi1 stabilizes cyclin A in the embryo and requires zinc for its APC inhibitory activity. We find that Emi1 binds the substrate-binding region of Cdc20 and prevents substrate binding to the APC, illustrating a novel mechanism of APC inhibition.

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Year:  2001        PMID： 11751633      PMCID： PMC312853          DOI： 10.1101/gad.945701

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  44 in total

1.  Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities.

Authors:  Y Wan; M W Kirschner
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-30       Impact factor: 11.205

2.  Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.

Authors:  C M Pfleger; A Salic; E Lee; M W Kirschner
Journal:  Genes Dev       Date:  2001-07-15       Impact factor: 11.361

3.  Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation.

Authors:  Y Zhang; E Lees
Journal:  Mol Cell Biol       Date:  2001-08       Impact factor: 4.272

4.  Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.

Authors:  C M Pfleger; E Lee; M W Kirschner
Journal:  Genes Dev       Date:  2001-09-15       Impact factor: 11.361

5.  Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints.

Authors:  D A Skoufias; P R Andreassen; F B Lacroix; L Wilson; R L Margolis
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

6.  Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

Authors:  A Abrieu; L Magnaghi-Jaulin; J A Kahana; M Peter; A Castro; S Vigneron; T Lorca; D W Cleveland; J C Labbé
Journal:  Cell       Date:  2001-07-13       Impact factor: 41.582

7.  The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner.

Authors:  Z Hilioti; Y S Chung; Y Mochizuki; C F Hardy; O Cohen-Fix
Journal:  Curr Biol       Date:  2001-09-04       Impact factor: 10.834

8.  MAD2B is an inhibitor of the anaphase-promoting complex.

Authors:  J Chen; G Fang
Journal:  Genes Dev       Date:  2001-07-15       Impact factor: 11.361

9.  A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.

Authors:  C S Sørensen; C Lukas; E R Kramer; J M Peters; J Bartek; J Lukas
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

10.  Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.

Authors:  V Sudakin; G K Chan; T J Yen
Journal:  J Cell Biol       Date:  2001-09-03       Impact factor: 10.539
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  77 in total

1.  Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway.

Authors:  Anna Castro; Suzanne Vigneron; Cyril Bernis; Jean-Claude Labbé; Thierry Lorca
Journal:  Mol Cell Biol       Date:  2003-06       Impact factor: 4.272

2.  Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest.

Authors:  Keita Ohsumi; Ayako Koyanagi; Tomomi M Yamamoto; Tetsuya Gotoh; Takeo Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205

3.  Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

Authors:  David V Hansen; Alexander V Loktev; Kenneth H Ban; Peter K Jackson
Journal:  Mol Biol Cell       Date:  2004-10-06       Impact factor: 4.138

Review 4.  Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle.

Authors:  Xiomaris M Cotto-Rios; Mathew J K Jones; Tony T Huang
Journal:  Cell Cycle       Date:  2011-12-01       Impact factor: 4.534

5.  Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

Authors:  Andreas Schmidt; Peter I Duncan; Nadine R Rauh; Guido Sauer; Andrew M Fry; Erich A Nigg; Thomas U Mayer
Journal:  Genes Dev       Date:  2005-02-15       Impact factor: 11.361

6.  In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy.

Authors:  Zifu Wang; Jagesh V Shah; Michael W Berns; Don W Cleveland
Journal:  Biophys J       Date:  2006-04-07       Impact factor: 4.033

7.  Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Authors:  Julie J Miller; Matthew K Summers; David V Hansen; Maxence V Nachury; Norman L Lehman; Alex Loktev; Peter K Jackson
Journal:  Genes Dev       Date:  2006-08-18       Impact factor: 11.361

8.  The Anaphase-Promoting Complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction.

Authors:  Jennifer R Kowalski; Hitesh Dube; Denis Touroutine; Kristen M Rush; Patricia R Goodwin; Marc Carozza; Zachary Didier; Michael M Francis; Peter Juo
Journal:  Mol Cell Neurosci       Date:  2013-12-07       Impact factor: 4.314

9.  A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

Authors:  Jeffrey J Tung; David V Hansen; Kenneth H Ban; Alexander V Loktev; Matthew K Summers; John R Adler; Peter K Jackson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-07       Impact factor: 11.205

10.  Cdc28 and Cdc14 control stability of the anaphase-promoting complex inhibitor Acm1.

Authors:  Mark C Hall; Dah-Eun Jeong; James T Henderson; Eunyoung Choi; Steven C Bremmer; Anton B Iliuk; Harry Charbonneau
Journal:  J Biol Chem       Date:  2008-02-20       Impact factor: 5.157
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