Literature DB >> 11459825

Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.

C M Pfleger1, A Salic, E Lee, M W Kirschner.   

Abstract

Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1. Cdc20-APC is regulated through inhibition by the spindle assembly checkpoint protein MAD2. Knowledge of Cdh1-APC regulation is limited to the phosphorylation-dependent dissociation of Cdh1 from APC. We report a novel means of regulating Cdh1 by the MAD2-related gene, MAD2L2. MAD2L2 specifically binds and inhibits Cdh1-APC, paralleling the effect of MAD2 on Cdc20. We suggest that MAD2L2 and MAD2 inhibit the release of substrates from APC and propose a mechanism of inhibition.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11459825      PMCID： PMC312740          DOI： 10.1101/gad.897901

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  33 in total

Review 1.  Whose end is destruction: cell division and the anaphase-promoting complex.

Authors:  W Zachariae; K Nasmyth
Journal:  Genes Dev       Date:  1999-08-15       Impact factor: 11.361

Review 2.  The ubiquitin system.

Authors:  A Hershko; A Ciechanover
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

3.  Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.

Authors:  C Gieffers; B H Peters; E R Kramer; C G Dotti; J M Peters
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

4.  Characterization of MAD2B and other mitotic spindle checkpoint genes.

Authors:  D P Cahill; L T da Costa; E B Carson-Walter; K W Kinzler; B Vogelstein; C Lengauer
Journal:  Genomics       Date:  1999-06-01       Impact factor: 5.736

5.  Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.

Authors:  G Fang; H Yu; M W Kirschner
Journal:  Mol Cell       Date:  1998-08       Impact factor: 17.970

6.  Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

Authors:  S L Jaspersen; J F Charles; D O Morgan
Journal:  Curr Biol       Date:  1999-03-11       Impact factor: 10.834

7.  Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.

Authors:  H Zou; T J McGarry; T Bernal; M W Kirschner
Journal:  Science       Date:  1999-07-16       Impact factor: 47.728

8.  Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts.

Authors:  T Lorca; A Castro; A M Martinez; S Vigneron; N Morin; S Sigrist; C Lehner; M Dorée; J C Labbé
Journal:  EMBO J       Date:  1998-07-01       Impact factor: 11.598

9.  The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis.

Authors:  S Prinz; E S Hwang; R Visintin; A Amon
Journal:  Curr Biol       Date:  1998-06-18       Impact factor: 10.834

10.  Regulation of APC activity by phosphorylation and regulatory factors.

Authors:  S Kotani; H Tanaka; H Yasuda; K Todokoro
Journal:  J Cell Biol       Date:  1999-08-23       Impact factor: 10.539
View more
  53 in total

1.  Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.

Authors:  L Sironi; M Melixetian; M Faretta; E Prosperini; K Helin; A Musacchio
Journal:  EMBO J       Date:  2001-11-15       Impact factor: 11.598

2.  Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.

Authors:  J D Reimann; B E Gardner; F Margottin-Goguet; P K Jackson
Journal:  Genes Dev       Date:  2001-12-15       Impact factor: 11.361

3.  Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex.

Authors:  Guowei Fang
Journal:  Mol Biol Cell       Date:  2002-03       Impact factor: 4.138

4.  Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.

Authors:  C M Pfleger; E Lee; M W Kirschner
Journal:  Genes Dev       Date:  2001-09-15       Impact factor: 11.361

5.  Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.

Authors:  Lucia Sironi; Marina Mapelli; Stefan Knapp; Anna De Antoni; Kuan-Teh Jeang; Andrea Musacchio
Journal:  EMBO J       Date:  2002-05-15       Impact factor: 11.598

6.  The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.

Authors:  Lauren S Waters; Graham C Walker
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-02       Impact factor: 11.205

Review 7.  Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance.

Authors:  Lauren S Waters; Brenda K Minesinger; Mary Ellen Wiltrout; Sanjay D'Souza; Rachel V Woodruff; Graham C Walker
Journal:  Microbiol Mol Biol Rev       Date:  2009-03       Impact factor: 11.056

8.  Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1.

Authors:  Yuan Zhou; Yick-Pang Ching; Raymond W M Ng; Dong-Yan Jin
Journal:  Biochem J       Date:  2003-09-01       Impact factor: 3.857

Review 9.  Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis.

Authors:  Jinfang Zhang; Lixin Wan; Xiangpeng Dai; Yi Sun; Wenyi Wei
Journal:  Biochim Biophys Acta       Date:  2014-02-22

10.  MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.

Authors:  Chun-Fu Hong; Yu-Ting Chou; Young-Sun Lin; Cheng-Wen Wu
Journal:  J Biol Chem       Date:  2009-05-14       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.