Literature DB >> 11751150

Pharmacodynamic interaction of doxycycline and artemisinin in Plasmodium falciparum.

Ulrike Sponer1, Somsak Prajakwong, Gerhard Wiedermann, Herwig Kollaritsch, Gunther Wernsdorfer, Walther H Wernsdorfer.   

Abstract

Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC(50)), EC(90), and EC(99) levels.

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Year:  2002        PMID： 11751150      PMCID： PMC126969          DOI： 10.1128/AAC.46.1.262-264.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Authors:  A S Budimulja; P Tapchaisri; P Wilairat; S Marzuki
Journal:  Mol Biochem Parasitol       Date:  1997-01       Impact factor: 1.759

2.  Activity of artemether-azithromycin versus artemether-doxycycline in the treatment of multiple drug resistant falciparum malaria.

Authors:  K Na-Bangchang; T Kanda; P Tipawangso; A Thanavibul; K Suprakob; M Ibrahim; Y Wattanagoon; J Karbwang
Journal:  Southeast Asian J Trop Med Public Health       Date:  1996-09       Impact factor: 0.267

3.  Efficacy of artemisinin and mefloquine combinations against Plasmodium falciparum. In vitro simulation of in vivo pharmacokinetics.

Authors:  B Bwijo; M H Alin; N Abbas; W Wernsdorfer; A Björkman
Journal:  Trop Med Int Health       Date:  1997-05       Impact factor: 2.622

4.  Mefloquine-resistant falciparum malaria on the Thai-Burmese border.

Authors:  F Nosten; F ter Kuile; T Chongsuphajaisiddhi; C Luxemburger; H K Webster; M Edstein; L Phaipun; K L Thew; N J White
Journal:  Lancet       Date:  1991-05-11       Impact factor: 79.321

Review 5.  Epidemiology of drug resistance in malaria.

Authors:  W H Wernsdorfer
Journal:  Acta Trop       Date:  1994-03       Impact factor: 3.112

6.  Treatment of malaria in Vietnam with oral artemisinin.

Authors:  D S Nguyen; B H Dao; P D Nguyen; V H Nguyen; N B Le; V S Mai; S R Meshnick
Journal:  Am J Trop Med Hyg       Date:  1993-03       Impact factor: 2.345

7.  WHO Expert Committee on Malaria.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  2000

8.  Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine.

Authors:  S Looareesuwan; D E Kyle; C Viravan; S Vanijanonta; P Wilairatana; P Charoenlarp; C J Canfield; H K Webster
Journal:  Am J Trop Med Hyg       Date:  1992-12       Impact factor: 2.345

9.  Randomized trial of mefloquine-doxycycline, and artesunate-doxycycline for treatment of acute uncomplicated falciparum malaria.

Authors:  S Looareesuwan; C Viravan; S Vanijanonta; P Wilairatana; P Charoenlarp; C J Canfield; D E Kyle
Journal:  Am J Trop Med Hyg       Date:  1994-06       Impact factor: 2.345

10.  Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

Authors:  S R Meshnick; Y Z Yang; V Lima; F Kuypers; S Kamchonwongpaisan; Y Yuthavong
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191
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  6 in total

1.  Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.

Authors:  Paul N Newton; Jean-François Chaulet; Alan Brockman; Wirongrong Chierakul; Arjen Dondorp; Ronatrai Ruangveerayuth; Sornchai Looareesuwan; Cyril Mounier; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

2.  In vitro and in vivo antimalarial efficacies of optimized tetracyclines.

Authors:  Michael P Draper; Beena Bhatia; Haregewein Assefa; Laura Honeyman; Lynne K Garrity-Ryan; Atul K Verma; Jiri Gut; Kelley Larson; Janice Donatelli; Ann Macone; Kevin Klausner; Raina G Leahy; Aleksandrs Odinecs; Kwasi Ohemeng; Philip J Rosenthal; Mark L Nelson
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191

3.  Antimalarial activity of tigecycline, a novel glycylcycline antibiotic.

Authors:  P Starzengruber; K Thriemer; R Haque; W A Khan; H P Fuehrer; A Siedl; V Hofecker; B Ley; W H Wernsdorfer; H Noedl
Journal:  Antimicrob Agents Chemother       Date:  2009-07-13       Impact factor: 5.191

4.  Pharmacodynamics of doxycycline in a murine malaria model.

Authors:  Kevin T Batty; Angela S F Law; Verity Stirling; Brioni R Moore
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

5.  In vitro activity of mirincamycin (U24729A) against Plasmodium falciparum isolates from Gabon.

Authors:  Jana Held; Richard Westerman; Peter G Kremsner; Benjamin Mordmüller
Journal:  Antimicrob Agents Chemother       Date:  2009-10-19       Impact factor: 5.191

6.  Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system.

Authors:  Anat Florentin; Dylon R Stephens; Carrie F Brooks; Rodrigo P Baptista; Vasant Muralidharan
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-01       Impact factor: 11.205
  6 in total

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