Literature DB >> 17876000

Pharmacodynamics of doxycycline in a murine malaria model.

Kevin T Batty1, Angela S F Law, Verity Stirling, Brioni R Moore.   

Abstract

Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.

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Year:  2007        PMID： 17876000      PMCID： PMC2167965          DOI： 10.1128/AAC.00529-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Pharmacodynamic interaction of doxycycline and artemisinin in Plasmodium falciparum.

Authors:  Ulrike Sponer; Somsak Prajakwong; Gerhard Wiedermann; Herwig Kollaritsch; Gunther Wernsdorfer; Walther H Wernsdorfer
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

Review 2.  The assessment of antimalarial drug efficacy.

Authors:  Nicholas J White
Journal:  Trends Parasitol       Date:  2002-10

3.  The chemotherapy of rodent malaria, XIX. The action of a tetracycline derivative, minocycline, on drug-resistant Plasmodium berghei.

Authors:  J B Kaddu; D C Warhurst; W Peters
Journal:  Ann Trop Med Parasitol       Date:  1974-03

4.  Interaction of artemisinin and tetracycline or erythromycin against Plasmodium falciparum in vitro.

Authors:  Z Ye; K Van Dyke
Journal:  Parasite       Date:  1994-09       Impact factor: 3.000

5.  Effects of antibiotics on Plasmodium falciparum in vitro.

Authors:  T G Geary; J B Jensen
Journal:  Am J Trop Med Hyg       Date:  1983-03       Impact factor: 2.345

Review 6.  Falciparum malaria: the urgent need for safe and effective drugs.

Authors:  K H Rieckmann
Journal:  Annu Rev Med       Date:  1983       Impact factor: 13.739

7.  The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.

Authors:  Q L Fivelman; J C Walden; P J Smith; P I Folb; K I Barnes
Journal:  Trans R Soc Trop Med Hyg       Date:  1999 Jul-Aug       Impact factor: 2.184

8.  Therapeutic responses to antibacterial drugs in vivax malaria.

Authors:  S Pukrittayakamee; R Clemens; A Chantra; A Nontprasert; T Luknam; S Looareesuwan; N J White
Journal:  Trans R Soc Trop Med Hyg       Date:  2001 Sep-Oct       Impact factor: 2.184

9.  Comparison of distribution of doxycycline in mice after oral and intravenous application measured by a high-performance liquid chromatographic method.

Authors:  R Böcker; C J Estler; M Maywald; D Weber
Journal:  Arzneimittelforschung       Date:  1981

10.  Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin.

Authors:  Peter L Gibbons; Kevin T Batty; P Hugh R Barrett; Timothy M E Davis; Kenneth F Ilett
Journal:  Int J Parasitol       Date:  2007-05-18       Impact factor: 3.981
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  7 in total

1.  Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.

Authors:  Brioni R Moore; Madhu Page-Sharp; Jillian R Stoney; Kenneth F Ilett; Jeffrey D Jago; Kevin T Batty
Journal:  Antimicrob Agents Chemother       Date:  2011-06-06       Impact factor: 5.191

Review 2.  Modelling the time course of antimalarial parasite killing: a tour of animal and human models, translation and challenges.

Authors:  Kashyap Patel; Julie A Simpson; Kevin T Batty; Sophie Zaloumis; Carl M Kirkpatrick
Journal:  Br J Clin Pharmacol       Date:  2015-01       Impact factor: 4.335

3.  Genetic-code-expanded cell-based therapy for treating diabetes in mice.

Authors:  Chao Chen; Guiling Yu; Yujia Huang; Wenhui Cheng; Yuxuan Li; Yi Sun; Haifeng Ye; Tao Liu
Journal:  Nat Chem Biol       Date:  2021-11-15       Impact factor: 15.040

4.  Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice.

Authors:  John C Crabbe; Angela R Ozburn; Robert J Hitzemann; Stephanie E Spence; Wyatt R Hack; Jason P Schlumbohm; Pamela Metten
Journal:  Brain Behav Immun Health       Date:  2020-03-19

5.  Piperaquine pharmacodynamics and parasite viability in a murine malaria model.

Authors:  Brioni R Moore; Kenneth F Ilett; Madhu Page-Sharp; Jeffrey D Jago; Kevin T Batty
Journal:  Antimicrob Agents Chemother       Date:  2009-04-20       Impact factor: 5.191

6.  Superior Pyronaridine Single-Dose Pharmacodynamics Compared to Artesunate, Chloroquine, and Amodiaquine in a Murine Malaria Luciferase Model.

Authors:  Winter A Okoth; Elijah J Dukes; David J Sullivan
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

7.  Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators.

Authors:  Kim E Schmidt; Janina M Kuepper; Beatrix Schumak; Judith Alferink; Andrea Hofmann; Shanshan W Howland; Laurent Rénia; Andreas Limmer; Sabine Specht; Achim Hoerauf
Journal:  PLoS One       Date:  2018-02-13       Impact factor: 3.240
  7 in total

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