Literature DB >> 19596882

Antimalarial activity of tigecycline, a novel glycylcycline antibiotic.

P Starzengruber1, K Thriemer, R Haque, W A Khan, H P Fuehrer, A Siedl, V Hofecker, B Ley, W H Wernsdorfer, H Noedl.   

Abstract

Tigecycline is a novel glycylcycline antibiotic with a broad antibacterial spectrum. Tigecycline was tested with 66 clinical isolates of Plasmodium falciparum from Bangladesh using the histidine-rich protein 2 in vitro drug susceptibility assay. The 50% and 90% inhibitory concentrations of tigecycline were 699 (95% confidence interval, 496 to 986) and 5,905 nM (4,344 to 8,028). Tigecycline shows no activity correlation with traditional antimalarials and has substantial antimalarial activity on its own.

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Year:  2009        PMID： 19596882      PMCID： PMC2737841          DOI： 10.1128/AAC.00312-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Histidine-rich protein II: a novel approach to malaria drug sensitivity testing.

Authors:  Harald Noedl; Walther H Wernsdorfer; Robert Scott Miller; Chansuda Wongsrichanalai
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

2.  In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome.

Authors:  Harald Noedl; Srivicha Krudsood; Wattana Leowattana; Noppadon Tangpukdee; Wipa Thanachartwet; Sornchai Looareesuwan; Robert Scott Miller; Mark Fukuda; Krisada Jongsakul; Kritsanai Yingyuen; Sabaithip Sriwichai; Colin Ohrt; Charles Knirsch
Journal:  Antimicrob Agents Chemother       Date:  2006-11-20       Impact factor: 5.191

3.  Simple histidine-rich protein 2 double-site sandwich enzyme-linked immunosorbent assay for use in malaria drug sensitivity testing.

Authors:  Harald Noedl; Jan Bronnert; Kritsanai Yingyuen; Bernhard Attlmayr; Herwig Kollaritsch; Mark Fukuda
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

4.  A histidine-rich protein 2-based malaria drug sensitivity assay for field use.

Authors:  Harald Noedl; Bernhard Attlmayr; Walther H Wernsdorfer; Herwig Kollaritsch; Robert S Miller
Journal:  Am J Trop Med Hyg       Date:  2004-12       Impact factor: 2.345

Review 5.  Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

Authors:  Kenneth N Agwuh; Alasdair MacGowan
Journal:  J Antimicrob Chemother       Date:  2006-07-01       Impact factor: 5.790

6.  Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects.

Authors:  Gopal Muralidharan; Marlynne Micalizzi; John Speth; Donald Raible; Steven Troy
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

7.  Effects of age and sex on single-dose pharmacokinetics of tigecycline in healthy subjects.

Authors:  Gopal Muralidharan; Richard J Fruncillo; Marlynne Micalizzi; Donald G Raible; Steven M Troy
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

Review 8.  Tigecycline: in-vitro performance as a predictor of clinical efficacy.

Authors:  P Hawkey; R Finch
Journal:  Clin Microbiol Infect       Date:  2007-04       Impact factor: 8.067

9.  The effects of anti-bacterials on the malaria parasite Plasmodium falciparum.

Authors:  Christopher Dean Goodman; Vanessa Su; Geoffrey I McFadden
Journal:  Mol Biochem Parasitol       Date:  2007-01-09       Impact factor: 1.759

10.  In vitro activity and interaction of clindamycin combined with dihydroartemisinin against Plasmodium falciparum.

Authors:  M Ramharter; H Noedl; H Winkler; W Graninger; W H Wernsdorfer; P G Kremsner; S Winkler
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191
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  6 in total

1.  In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.

Authors:  Rajnish Sahu; Larry A Walker; Babu L Tekwani
Journal:  Malar J       Date:  2014-10-21       Impact factor: 2.979

Review 2.  Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria?

Authors:  Tiphaine Gaillard; Marylin Madamet; Francis Foguim Tsombeng; Jérôme Dormoi; Bruno Pradines
Journal:  Malar J       Date:  2016-11-15       Impact factor: 2.979

3.  Identifying Protein Features Responsible for Improved Drug Repurposing Accuracies Using the CANDO Platform: Implications for Drug Design.

Authors:  William Mangione; Ram Samudrala
Journal:  Molecules       Date:  2019-01-04       Impact factor: 4.411

Review 4.  Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action.

Authors:  Lais Pessanha de Carvalho; Andrea Kreidenweiss; Jana Held
Journal:  Molecules       Date:  2021-04-15       Impact factor: 4.411

Review 5.  Multipurpose Drugs Active Against Both Plasmodium spp. and Microorganisms: Potential Application for New Drug Development.

Authors:  Takuro Endo; Hitoshi Takemae; Indu Sharma; Tetsuya Furuya
Journal:  Front Cell Infect Microbiol       Date:  2021-12-24       Impact factor: 5.293

6.  Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates.

Authors:  Peter Starzengruber; Hans-Peter Fuehrer; Paul Swoboda; Deepa Ganesh; Rashidul Haque; Wasif A Khan; Wolfgang Graninger; Harald Noedl
Journal:  Malar J       Date:  2014-06-10       Impact factor: 2.979
  6 in total

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