Literature DB >> 11742081

Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element.

S U Emerson1, M Zhang, X J Meng, H Nguyen, M St Claire, S Govindarajan, Y K Huang, R H Purcell.   

Abstract

Hepatitis E virus recombinant genomes transcribed in vitro from two cDNA clones differing by two nucleotides were infectious for chimpanzees. However, one cDNA clone encoded a virus that was attenuated for chimpanzees and unable to infect rhesus monkeys. The second cDNA clone encoded a virus that infected both chimpanzees and rhesus monkeys and caused acute hepatitis in both. One mutation differentiating the two clones identified a cis-reactive element that appeared to overlap the 3' end of the capsid gene and part of the 3' noncoding region. Capping of the RNA transcripts was essential for infectivity.

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Year:  2001        PMID： 11742081      PMCID： PMC65019          DOI： 10.1073/pnas.251555098

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  A novel virus in swine is closely related to the human hepatitis E virus.

Authors:  X J Meng; R H Purcell; P G Halbur; J R Lehman; D M Webb; T S Tsareva; J S Haynes; B J Thacker; S U Emerson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

2.  Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo.

Authors:  M Yanagi; M St Claire; M Shapiro; S U Emerson; R H Purcell; J Bukh
Journal:  Virology       Date:  1998-04-25       Impact factor: 3.616

3.  Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee.

Authors:  M Yanagi; R H Purcell; S U Emerson; J Bukh
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

4.  Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells.

Authors:  R A Robinson; W H Burgess; S U Emerson; R S Leibowitz; S A Sosnovtseva; S Tsarev; R H Purcell
Journal:  Protein Expr Purif       Date:  1998-02       Impact factor: 1.650

5.  The in vitro-synthesized RNA from a cDNA clone of hepatitis E virus is infectious.

Authors:  S K Panda; I H Ansari; H Durgapal; S Agrawal; S Jameel
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

6.  Evidence that the genomic RNA of hepatitis E virus is capped.

Authors:  Y Kabrane-Lazizi; X J Meng; R H Purcell; S U Emerson
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

7.  Evidence for widespread infection of wild rats with hepatitis E virus in the United States.

Authors:  Y Kabrane-Lazizi; J B Fine; J Elm; G E Glass; H Higa; A Diwan; C J Gibbs; X J Meng; S U Emerson; R H Purcell
Journal:  Am J Trop Med Hyg       Date:  1999-08       Impact factor: 2.345

8.  Evaluation of assays for antibody to hepatitis E virus by a serum panel. Hepatitis E Virus Antibody Serum Panel Evaluation Group.

Authors:  E E Mast; M J Alter; P V Holland; R H Purcell
Journal:  Hepatology       Date:  1998-03       Impact factor: 17.425

9.  Genetic and experimental evidence for cross-species infection by swine hepatitis E virus.

Authors:  X J Meng; P G Halbur; M S Shapiro; S Govindarajan; J D Bruna; I K Mushahwar; R H Purcell; S U Emerson
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

10.  Experimental hepatitis E in pregnant rhesus monkeys: failure to transmit hepatitis E virus (HEV) to offspring and evidence of naturally acquired antibodies to HEV.

Authors:  S A Tsarev; T S Tsareva; S U Emerson; M K Rippy; P Zack; M Shapiro; R H Purcell
Journal:  J Infect Dis       Date:  1995-07       Impact factor: 5.226
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  63 in total

1.  Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.

Authors:  P Shukla; H T Nguyen; K Faulk; K Mather; U Torian; R E Engle; S U Emerson
Journal:  J Virol       Date:  2012-03-07       Impact factor: 5.103

2.  Hepatobiliary quiz-7 (2013).

Authors:  Swastik Agrawal; Radha K Dhiman
Journal:  J Clin Exp Hepatol       Date:  2013-09

3.  ORF3 protein of hepatitis E virus is not required for replication, virion assembly, or infection of hepatoma cells in vitro.

Authors:  Suzanne U Emerson; Hanh Nguyen; Udana Torian; Robert H Purcell
Journal:  J Virol       Date:  2006-08-23       Impact factor: 5.103

4.  In vitro and in vivo mutational analysis of the 3'-terminal regions of hepatitis e virus genomes and replicons.

Authors:  Judith Graff; Hanh Nguyen; Chaiyan Kasorndorkbua; Patrick G Halbur; Marisa St Claire; Robert H Purcell; Suzanne U Emerson
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

5.  Enhancement of interferon induction by ORF3 product of hepatitis E virus.

Authors:  Yuchen Nan; Zexu Ma; Rong Wang; Ying Yu; Harilakshmi Kannan; Brenda Fredericksen; Yan-Jin Zhang
Journal:  J Virol       Date:  2014-05-21       Impact factor: 5.103

6.  Hepatitis E vaccine.

Authors:  Rakesh Aggarwal; Shahid Jameel
Journal:  Hepatol Int       Date:  2008-04-10       Impact factor: 6.047

7.  Antiviral Candidates for Treating Hepatitis E Virus Infection.

Authors:  Natalie E Netzler; Daniel Enosi Tuipulotu; Subhash G Vasudevan; Jason M Mackenzie; Peter A White
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

8.  Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3.

Authors:  Heléne Norder; Cristina Galli; Ellen Magnil; Per Sikora; Elisabet Ekvärn; Kristina Nyström; Lars O Magnius
Journal:  Intervirology       Date:  2018-10-02       Impact factor: 1.763

9.  In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein.

Authors:  Suzanne U Emerson; Hanh Nguyen; Judith Graff; David A Stephany; Alicia Brockington; Robert H Purcell
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

10.  Experimental infection of rabbits with rabbit and genotypes 1 and 4 hepatitis E viruses.

Authors:  Hongxia Ma; Lin Zheng; Yunbo Liu; Chenyan Zhao; Tim J Harrison; Yuyuan Ma; Shuhua Sun; Jingang Zhang; Youchun Wang
Journal:  PLoS One       Date:  2010-02-11       Impact factor: 3.240
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