Literature DB >> 30278453

Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3.

Heléne Norder1, Cristina Galli1,2, Ellen Magnil1, Per Sikora3,4, Elisabet Ekvärn5, Kristina Nyström1, Lars O Magnius6.   

Abstract

Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have identified HEV RNA in blood products although its significance is not understood. This study was undertaken to characterize HEV genomes in asymptomatic plasma donors from Sweden and Germany lacking anti-HEV. Complete open reading frames (ORFs) were obtained from HEV strains in 5 out of 18 plasma donors who tested positive for HEV RNA. All strains had CUG as the start codon of ORF3, while 147 GenBank strains all had AUG as the start codon (p < 0.0001). This substitution was found in both interrelated and unrelated strains belonging to different phylogenetic clades. The HEV strains from the seronegative plasma donors had no other substitution in common, which may be why the CUG substitution seems to explain the seronegativity.
© 2018 The Author(s) Published by S. Karger AG, Basel.

Entities:  

Keywords:  Blood donors; HEV3; Mutation; Nucleotide sequence

Mesh：

Substances：

Year:  2018        PMID： 30278453      PMCID： PMC6262685          DOI： 10.1159/000491926

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  38 in total

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