| Literature DB >> 11741538 |
Y Wan1, X Liu, M W Kirschner.
Abstract
Degradation of SnoN is thought to play an important role in the transactivation of TGF-beta responsive genes. We demonstrate that the anaphase-promoting complex (APC) is a ubiquitin ligase required for the destruction of SnoN and that the APC pathway is regulated by TGF-beta. The destruction box of SnoN is required for its degradation in response to TGF-beta signaling. Furthermore, the APC activator CDH1 and Smad3 synergistically regulate SnoN degradation. Under these circumstances, CDH1 forms a quaternary complex with SnoN, Smad3, and APC. These results suggest that APC(CDH1) and SnoN play central roles in regulating growth through the TGF-beta signaling system.Entities:
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Year: 2001 PMID： 11741538 DOI： 10.1016/s1097-2765(01)00382-3
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970