Y Zhang1, Y Chu, Z Shao. 1. Institute of Hematology, CAMS, PUMC, Tianjin 300020.
Abstract
OBJECTIVE: To evaluate the clinical implications of IgG subclass in autoimmune hemolytic anemia(AIHA). METHODS: Data of 84 AIHA patients were retrospectively analyzed. RESULTS: In the 84 patients, IgG1 + IgG3 + C3d accounted for 45.0%, IgG1 + IgG3 15.5%, IgG1 + C3d 11.0%, C3d 10.7%, IgG1 9.5% and IgG3 + C3d 8.3%. IgG3 patients had the most severity of clinical and laboratory findings, followed by IgG1 patients. In IgG1 and IgG3 subgroups, the severity of hemolysis was positively correlated with the score of Coombs' test. The response rates of IgG3 and IgG1 patients were 68.2% and 100%, respectively. CONCLUSION: In AIHA, the basic predominant IgG subclass is IgG1. IgG3 has a greater potential for red-cell destruction than IgG1 and C3d.
OBJECTIVE: To evaluate the clinical implications of IgG subclass in autoimmune hemolytic anemia(AIHA). METHODS: Data of 84 AIHA patients were retrospectively analyzed. RESULTS: In the 84 patients, IgG1 + IgG3 + C3d accounted for 45.0%, IgG1 + IgG3 15.5%, IgG1 + C3d 11.0%, C3d 10.7%, IgG1 9.5% and IgG3 + C3d 8.3%. IgG3patients had the most severity of clinical and laboratory findings, followed by IgG1 patients. In IgG1 and IgG3 subgroups, the severity of hemolysis was positively correlated with the score of Coombs' test. The response rates of IgG3 and IgG1 patients were 68.2% and 100%, respectively. CONCLUSION: In AIHA, the basic predominant IgG subclass is IgG1. IgG3 has a greater potential for red-cell destruction than IgG1 and C3d.