Literature DB >> 11720535

Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens.

G A Wächter1, S G Franzblau, G Montenegro, J J Hoffmann, W M Maiese, B N Timmermann.   

Abstract

Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Vero cells was observed for this compound. Saringosterol was also synthesized by oxidation of fucosterol. The MIC values for antitubercular activity of saringosterol and its 24S and 24R epimers were determined as 0.25, 1, and 0.125 microg/mL.

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Year:  2001        PMID： 11720535     DOI： 10.1021/np010101q

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera.

Authors:  Rosario Rojas; Luz Caviedes; José C Aponte; Abraham J Vaisberg; Walter H Lewis; Gerardo Lamas; César Sarasara; Robert H Gilman; Gerald B Hammond
Journal:  J Nat Prod       Date:  2006-05       Impact factor: 4.050

Review 2.  Health benefits of microalgae and their microbiomes.

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Journal:  Microb Biotechnol       Date:  2022-05-29       Impact factor: 6.575

3.  Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis.

Authors:  Xiaomei Wei; Abimael D Rodríguez; Yuehong Wang; Scott G Franzblau
Journal:  Bioorg Med Chem Lett       Date:  2008-09-11       Impact factor: 2.823

4.  Synergistic Antimycobacterial Actions of Knowltonia vesicatoria (L.f) Sims.

Authors:  Antoinette Labuschagné; Ahmed A Hussein; Benjamín Rodríguez; Namrita Lall
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-07       Impact factor: 2.629

Review 5.  Advances in Microalgae-Derived Phytosterols for Functional Food and Pharmaceutical Applications.

Authors:  Xuan Luo; Peng Su; Wei Zhang
Journal:  Mar Drugs       Date:  2015-07-09       Impact factor: 5.118

6.  Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge Haliclona simulans.

Authors:  Christina Viegelmann; Jennifer Parker; Thengtheng Ooi; Carol Clements; Gráinne Abbott; Louise Young; Jonathan Kennedy; Alan D W Dobson; RuAngelie Edrada-Ebel
Journal:  Mar Drugs       Date:  2014-05-16       Impact factor: 5.118

7.  Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens.

Authors:  Nasrin Payghami; Shahla Jamili; Abdolhossein Rustaiyan; Soodabeh Saeidnia; Marjan Nikan; Ahmad Reza Gohari
Journal:  Pharmacognosy Res       Date:  2014 Oct-Dec

8.  Brown Algae (Phaeophyceae) from the Coast of Madagascar: preliminary Bioactivity Studies and Isolation of Natural Products.

Authors:  Marie Pascaline Rahelivao; Margit Gruner; Hanta Andriamanantoanina; Ingmar Bauer; Hans-Joachim Knölker
Journal:  Nat Prod Bioprospect       Date:  2015-09-10

9.  Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments.

Authors:  Sherif T S Hassan
Journal:  Biomedicines       Date:  2020-05-24

Review 10.  Antimicrobials from Seaweeds for Food Applications.

Authors:  Eduarda M Cabral; Márcia Oliveira; Julie R M Mondala; James Curtin; Brijesh K Tiwari; Marco Garcia-Vaquero
Journal:  Mar Drugs       Date:  2021-04-11       Impact factor: 5.118
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