Literature DB >> 11720480

AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma.

E Rivera1, O Arrieta, P Guevara, A Duarte-Rojo, J Sotelo.   

Abstract

Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor. Copyright 2001 Cancer Research Campaign

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Year:  2001        PMID： 11720480      PMCID： PMC2375243          DOI： 10.1054/bjoc.2001.2102

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  30 in total

1.  C6 rat glioma grown into the peritoneal cavity, a large source of tumoral cells for subcutaneous transplant of glioma.

Authors:  P Guevara; J Sotelo
Journal:  J Neurooncol       Date:  1999-08       Impact factor: 4.130

Review 2.  Brain tumors.

Authors:  L M DeAngelis
Journal:  N Engl J Med       Date:  2001-01-11       Impact factor: 91.245

Review 3.  Angiotensin II type 1 receptor blockers.

Authors:  M Burnier
Journal:  Circulation       Date:  2001-02-13       Impact factor: 29.690

4.  Angiotensin II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells.

Authors:  Y Kawahara; M Sunako; T Tsuda; H Fukuzaki; Y Fukumoto; Y Takai
Journal:  Biochem Biophys Res Commun       Date:  1988-01-15       Impact factor: 3.575

5.  Neovascularization produced by angiotensin II.

Authors:  L A Fernandez; J Twickler; A Mead
Journal:  J Lab Clin Med       Date:  1985-02

6.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

7.  Captopril reduces aortic and microvascular growth in hypertensive and normotensive rats.

Authors:  D H Wang; R L Prewitt
Journal:  Hypertension       Date:  1990-01       Impact factor: 10.190

8.  [Duality of angiotensin II receptors and risk for stroke and cancer: what is the connection?].

Authors:  A Fournier; A Ghitu; R Darabont; H Mazouz; R Makdassi; S Canaple; A Rosa; L A Fernandez
Journal:  Presse Med       Date:  1999 May 1-8       Impact factor: 1.228

9.  Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist.

Authors:  Y Fujimoto; T Sasaki; A Tsuchida; K Chayama
Journal:  FEBS Lett       Date:  2001-04-27       Impact factor: 4.124

10.  Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.

Authors:  N Weidner; J P Semple; W R Welch; J Folkman
Journal:  N Engl J Med       Date:  1991-01-03       Impact factor: 91.245
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  25 in total

1.  Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.

Authors:  Victor A Levin; James Chan; Meenal Datta; Jennie L Yee; Rakesh K Jain
Journal:  J Neurooncol       Date:  2017-06-19       Impact factor: 4.130

2.  Effect of ANG II on endothelial cell apoptosis and survival and its impact on skeletal muscle angiogenesis after electrical stimulation.

Authors:  Micheline M de Resende; Andrew S Greene
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-04-25       Impact factor: 4.733

3.  Impact of Angiotensin-II receptor blockers on vasogenic edema in glioblastoma patients.

Authors:  Antoine Kourilsky; Guillaume Bertrand; Renata Ursu; Jennifer Doridam; Ciprian Barlog; Thierry Faillot; Emmanuel Mandonnet; Catherine Belin; Christine Levy; Antoine F Carpentier
Journal:  J Neurol       Date:  2016-01-11       Impact factor: 4.849

4.  Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction.

Authors:  Raisa Serpi; Anna-Maria Tolonen; Olli Tenhunen; Oskari Pieviläinen; Anna-Maria Kubin; Tommi Vaskivuo; Ylermi Soini; Risto Kerkelä; Hanna Leskinen; Heikki Ruskoaho
Journal:  Clin Transl Sci       Date:  2009-12       Impact factor: 4.689

Review 5.  Repurposing some older drugs that cross the blood-brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma.

Authors:  Dayle Rundle-Thiele; Richard Head; Leah Cosgrove; Jennifer H Martin
Journal:  Br J Clin Pharmacol       Date:  2015-10-30       Impact factor: 4.335

Review 6.  The renin-angiotensin system and cancer: old dog, new tricks.

Authors:  Amee J George; Walter G Thomas; Ross D Hannan
Journal:  Nat Rev Cancer       Date:  2010-10-22       Impact factor: 60.716

7.  The effect of angiotensin II and IV on ERK1/2 and CREB signalling in cultured rat astroglial cells.

Authors:  Adam Holownia; Jan J Braszko
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-10-19       Impact factor: 3.000

Review 8.  Renin angiotensin system and its role in biomarkers and treatment in gliomas.

Authors:  Alexander Perdomo-Pantoja; Sonia Iliana Mejía-Pérez; Liliana Gómez-Flores-Ramos; Montserrat Lara-Velazquez; Cordelia Orillac; Juan Luis Gómez-Amador; Talia Wegman-Ostrosky
Journal:  J Neurooncol       Date:  2018-02-16       Impact factor: 4.130

9.  AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist.

Authors:  Daniel R Rhodes; Bushra Ateeq; Qi Cao; Scott A Tomlins; Rohit Mehra; Bharathi Laxman; Shanker Kalyana-Sundaram; Robert J Lonigro; Beth E Helgeson; Mahaveer S Bhojani; Alnawaz Rehemtulla; Celina G Kleer; Daniel F Hayes; Peter C Lucas; Sooryanarayana Varambally; Arul M Chinnaiyan
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-01       Impact factor: 11.205

10.  Effect of angiotensin II type 1 receptor antagonist on tumor growth and angiogenesis in a xenograft model of human bladder cancer.

Authors:  Michio Kosugi; Akira Miyajima; Eiji Kikuchi; Takeo Kosaka; Yutaka Horiguchi; Masaru Murai
Journal:  Hum Cell       Date:  2007-02       Impact factor: 4.174
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