Literature DB >> 11680899

Single molecule detector for mass spectrometry with mass independent detection efficiency.

D Twerenbold1, D Gerber, D Gritti, Y Gonin, A Netuschill, F Rossel, D Schenker, J L Vuilleumier.   

Abstract

Experimental results from equimolar PEG and protein standards samples are presented from a MALDI-TOF mass spectrometer equipped with both ionizing detectors and the novel single molecule sensitive cryodetectors. The data are consistent with a model hypothesis suggesting that the observed decrease in signal strength in conventional ionizing detector MALDI-TOF mass spectrometers can be explained by the exponentially decreasing quantum efficiency of ionizing detectors. Cryodetectors, in contrast, have a mass independent detection efficiency of 100% on impact and provide additional information on the molecule state owing to the calorimetric nature of the detection mechanism.

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Year:  2001        PMID： 11680899     DOI： 10.1002/1615-9861(200101)1:1<66::AID-PROT66>3.0.CO;2-S

Source DB:  PubMed          Journal:  Proteomics        ISSN： 1615-9853            Impact factor:   3.984


  8 in total

1.  Proteomic profiling of a snake venom using high mass detection MALDI-TOF mass spectrometry.

Authors:  Oscar Yanes; Francesc X Avilés; Ryan Wenzel; Alexis Nazabal; Renato Zenobi; Juan J Calvete
Journal:  J Am Soc Mass Spectrom       Date:  2007-01-03       Impact factor: 3.109

2.  Characterization of ZnO Nanoparticles using Superconducting Tunnel Junction Cryodetection Mass Spectrometry.

Authors:  Logan D Plath; Zongyu Wang; Jiajun Yan; Krzysztof Matyjaszewski; Mark E Bier
Journal:  J Am Soc Mass Spectrom       Date:  2017-04-18       Impact factor: 3.109

3.  Exploring the "intensity fading" phenomenon in the study of noncovalent interactions by MALDI-TOF mass spectrometry.

Authors:  Oscar Yanes; Francesc X Aviles; Peter Roepstorff; Thomas J D Jørgensen
Journal:  J Am Soc Mass Spectrom       Date:  2006-11-09       Impact factor: 3.109

4.  The analysis of polystyrene and polystyrene aggregates into the mega dalton mass range by cryodetection MALDI TOF MS.

Authors:  Alexander A Aksenov; Mark E Bier
Journal:  J Am Soc Mass Spectrom       Date:  2007-11-01       Impact factor: 3.109

5.  Antioxidant activities of fractions of polymeric procyanidins from stem bark of Acacia confusa.

Authors:  Shu-Dong Wei; Hai-Chao Zhou; Yi-Ming Lin
Journal:  Int J Mol Sci       Date:  2011-02-15       Impact factor: 5.923

6.  Optimization and evaluation of magnetic bead separation combined with matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) for proteins profiling of peritoneal dialysis effluent.

Authors:  Na Guo; Qiong Wen; Zhi-Jian Li; Ri-Cong Xu; Fen-Fen Peng; Xue-Qing Yu
Journal:  Int J Mol Sci       Date:  2014-01-16       Impact factor: 5.923

7.  The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators.

Authors:  Sarah Sainsbury; Laura A Lane; Jingshan Ren; Robert J Gilbert; Nigel J Saunders; Carol V Robinson; David I Stuart; Raymond J Owens
Journal:  Nucleic Acids Res       Date:  2009-05-27       Impact factor: 16.971

8.  Neutral particle mass spectrometry with nanomechanical systems.

Authors:  Eric Sage; Ariel Brenac; Thomas Alava; Robert Morel; Cécilia Dupré; Mehmet Selim Hanay; Michael L Roukes; Laurent Duraffourg; Christophe Masselon; Sébastien Hentz
Journal:  Nat Commun       Date:  2015-03-10       Impact factor: 14.919
  8 in total

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