Literature DB >> 11679551

An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.

A Mavroidi1, E Tzelepi, A Tsakris, V Miriagou, D Sofianou, L S Tzouvelekis.   

Abstract

An extended-spectrum beta-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. bla(IBC-2) was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these beta-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-beta-lactams.

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Year:  2001        PMID： 11679551     DOI： 10.1093/jac/48.5.627

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  23 in total

Review 1.  Ambler class A extended-spectrum beta-lactamases in Pseudomonas aeruginosa: novel developments and clinical impact.

Authors:  Gerhard F Weldhagen; Laurent Poirel; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

2.  Rapid detection and sequence-specific differentiation of extended-spectrum beta-lactamase GES-2 from Pseudomonas aeruginosa by use of a real-time PCR assay.

Authors:  Gerhard F Weldhagen
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

3.  Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.

Authors:  Fernando Pasteran; Diego Faccone; Alejandro Petroni; Melina Rapoport; Marcelo Galas; Miryam Vázquez; Adriana Procopio
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

4.  Nomenclature of GES-type extended-spectrum beta-lactamases.

Authors:  Sang Hee Lee; Seok Hoon Jeong
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

5.  Pyrosequencing as a rapid tool for identification of GES-type extended-spectrum beta-lactamases.

Authors:  Laurent Poirel; Thierry Naas; Patrice Nordmann
Journal:  J Clin Microbiol       Date:  2006-08       Impact factor: 5.948

6.  GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa.

Authors:  S D Kotsakis; C C Papagiannitsis; E Tzelepi; N J Legakis; V Miriagou; L S Tzouvelekis
Journal:  Antimicrob Agents Chemother       Date:  2010-01-11       Impact factor: 5.191

7.  Characterization of metallo-beta-lactamase VIM-27, an A57S mutant of VIM-1 associated with Klebsiella pneumoniae ST147.

Authors:  C C Papagiannitsis; S D Kotsakis; E Petinaki; A C Vatopoulos; E Tzelepi; V Miriagou; L S Tzouvelekis
Journal:  Antimicrob Agents Chemother       Date:  2011-04-25       Impact factor: 5.191

8.  In vitro prediction of the evolution of GES-1 β-lactamase hydrolytic activity.

Authors:  Séverine Bontron; Laurent Poirel; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2015-01-05       Impact factor: 5.191

9.  Sequence-selective recognition of extended-spectrum beta-lactamase GES-2 by a competitive, peptide nucleic acid-based multiplex PCR assay.

Authors:  Gerhard F Weldhagen
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

10.  Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

Authors:  Jun-ichi Wachino; Yohei Doi; Kunikazu Yamane; Naohiro Shibata; Tetsuya Yagi; Takako Kubota; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191
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