| Literature DB >> 11672543 |
C A Benedict1, T A Banks, L Senderowicz, M Ko, W J Britt, A Angulo, P Ghazal, C F Ware.
Abstract
Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts. Signaling by the lymphotoxin (LT)-beta receptor or TNF receptor-1, but not Fas or TRAIL receptors, inhibits the cytopathicity and replication of human CMV by a nonapoptotic, reversible process that requires nuclear factor kappa B (NF-kappa B)-dependent induction of interferon-beta (IFN-beta). Efficient induction of IFN-beta requires virus infection and LT signaling, demonstrating the need for both host and viral factors in the curtailment of viral replication without cellular elimination. LT alpha-deficient mice and LT beta R-Fc transgenic mice were profoundly susceptible to murine CMV infection. Together, these results reveal an essential and conserved role for LTs in establishing host defense to CMV.Entities:
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Year: 2001 PMID： 11672543 DOI： 10.1016/s1074-7613(01)00222-9
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745