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Literature DB >> 116697

Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity.

H Ludwig, R Kuzmits, H Pietschmann, M M Müller.

Abstract

Activities of adenosine deaminase (ADA), adenosine kinase (AK), adenine phosphoribosyltransferase (APRT), hypoxanthine guanine phosphoribosyltransferase (HGPRT), and purine nucleoside phosphorylase (PNP), all enzymes of the purine interconversion system, were determined in lymphocytes of 25 patients with chronic lymphatic leukemia (CLL) and in 23 controls. A statistically significant decrease of PNP activities and a reduction of ADA activities at borderline levels were found in the patients, whereas for the other enzymes assayed no deviation from normal values was observed.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 116697 DOI： 10.1007/bf01014193

Source DB: PubMed Journal: Blut ISSN： 0006-5242

17 in total

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Authors: M P Uitendaal; C H de Bruyn; T L Oei; P Hösli
Journal: Adv Exp Med Biol Date: 1977 Impact factor: 2.622

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Authors: B Ramot; F Brok-Simoni; N Barnea; I Bank; F Holtzmann
Journal: Br J Haematol Date: 1977-05 Impact factor: 6.998

3. Demonstration of adenosine receptor on human lymphocytes in vitro and its possible role in the adenosine deaminase-deficient form of severe combined immunodeficiency.

Authors: A L Schwartz; R C Stern; S H Polmar
Journal: Clin Immunol Immunopathol Date: 1978-04

4. Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-234.

Authors:
Journal: Blood Date: 2016-10-27 Impact factor: 22.113

5. A specific enzyme defect in gout associated with overproduction of uric acid.

Authors: W N Kelley; F M Rosenbloom; J F Henderson; J E Seegmiller
Journal: Proc Natl Acad Sci U S A Date: 1967-06 Impact factor: 11.205

6. Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

Authors: M S Coleman; J Donofrio; J J Hutton; L Hahn; A Daoud; B Lampkin; J Dyminski
Journal: J Biol Chem Date: 1978-03-10 Impact factor: 5.157

7. A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism.

Authors: H A Simmonds; G S Panayi; V Corrigall
Journal: Lancet Date: 1978-01-14 Impact factor: 79.321

8. Control of pyrimidine biosynthesis in human lymphocytes. Inhibitory effect of guanine and guanosine on induction of enzymes for pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes.

Authors: K Ito; H Uchino
Journal: J Biol Chem Date: 1976-03-10 Impact factor: 5.157