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Literature DB >> 1063590

Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.

Abstract

Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myeloma, untreated lymphoma and leukaemic reticuloendotheliosis. High values were observed in lymphocytes from patients with lymphoma during intensive combination chemotherapy. ADA levels in lymphocytes were not correlated with levels in granulocytes or erythrocytes. ADA was elevated in blasts of patients with acute lymphocytic and myelogenous leukaemias but the ranges of activities per cell were so similar that ADA assay is unlikely to be of major help in distinguishing the two diseases.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1976 PMID： 1063590 PMCID： PMC2024973 DOI： 10.1038/bjc.1976.45

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

11 in total

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Authors: M S Coleman; J J Hutton
Journal: Exp Cell Res Date: 1975-09 Impact factor: 3.905

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Authors: D Catovsky; J E Pettit; J Galetto; A Okos; D A Galton
Journal: Br J Haematol Date: 1974-01 Impact factor: 6.998

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Authors: E R Giblett; J E Anderson; F Cohen; B Pollara; H J Meuwissen
Journal: Lancet Date: 1972-11-18 Impact factor: 79.321

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Authors: A Böyum
Journal: Scand J Clin Lab Invest Suppl Date: 1968

5. Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells.

Authors: E M Scholar; P Calabresi
Journal: Cancer Res Date: 1973-01 Impact factor: 12.701

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Authors: W R Osborne; N Spencer
Journal: Biochem J Date: 1973-05 Impact factor: 3.857

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Authors: H Akedo; H Nishihara; K Shinkai; K Komatsu; S Ishikawa
Journal: Biochim Biophys Acta Date: 1972-07-13

8. Effect of neuraminidase and papain treatment on lectin-induced agglutination of Novikoff tumor cells and assay of lectin receptor activity of the glycopeptides released from the cell surface by papain.

Authors: G Neri; M C Giuliano; S Capetillo; E B Gilliam; D C Hixson; E F Walborg
Journal: Cancer Res Date: 1976-01 Impact factor: 12.701

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Authors: R Parkman; E W Gelfand; F S Rosen; A Sanderson; R Hirschhorn
Journal: N Engl J Med Date: 1975-04-03 Impact factor: 91.245

10. Adenosine deaminase activity in leukaemia.

Authors: J F Smyth; K R Harrap
Journal: Br J Cancer Date: 1975-05 Impact factor: 7.640

13 in total

1. PORPHOBILINOGEN DEAMINASE AND ADENOSINE DEAMINASE ACTIVITY AS A POSSIBLE DIAGNOSTIC AID IN LYMPHATIC LEUKEMIAS.

Authors: Alka N Sontakke; Y V Sharma
Journal: Med J Armed Forces India Date: 2017-06-26

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Authors: J F Smyth; D G Poplack; B J Holiman; B G Leventhal; G Yarbro
Journal: J Clin Invest Date: 1978-09 Impact factor: 14.808

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Journal: J Clin Pathol Date: 1985-02 Impact factor: 3.411

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Authors: H Ludwig; R Kuzmits; H Pietschmann; M M Müller
Journal: Blut Date: 1979-11

5. Alteration of adenosine deaminase levels in peripheral blood lymphocytes of patients with gastric cancer.

Authors: O Kojima; T Majima; Y Uehara; T Yamane; Y Fujita; T Takahashi; S Majima
Journal: Jpn J Surg Date: 1985-03

6. Myelomatous pleural effusion as an initial sign of multiple myeloma-a case report and review of literature.

Authors: Li-Li Zhang; Yuan-Yuan Li; Cheng-Ping Hu; Hua-Ping Yang
Journal: J Thorac Dis Date: 2014-07 Impact factor: 2.895

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Authors: I Durak; N Ormeci; O Akyol; O Canbolat; M Kavutçu; M Bülbül
Journal: Dig Dis Sci Date: 1994-04 Impact factor: 3.199

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Authors: A V Hoffbrand; G Janossy
Journal: J Clin Pathol Date: 1981-03 Impact factor: 3.411

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Authors: L Skoog; B Nordenskjöld; A Ost; B Andersson; R Hast; N Giannoulis; S Humla; T Hägerström; P Reizenstein
Journal: Br Med J (Clin Res Ed) Date: 1981-06-06

10. Biochemical characterization of adenosine deaminase (CD26; EC 3.5.4.4) activity in human lymphocyte-rich peripheral blood mononuclear cells.

Authors: L R Costa; A K Y de Souza; J N Scholl; F Figueiró; A M O Battastini; J A Dos Santos Jaques; F F Zanoelo
Journal: Braz J Med Biol Res Date: 2021-05-24 Impact factor: 2.590