Literature DB >> 11598044

Salmonella DNA adenine methylase mutants confer cross-protective immunity.

D M Heithoff1, E Y Enioutina, R A Daynes, R L Sinsheimer, D A Low, M J Mahan.   

Abstract

Salmonella isolates that lack or overproduce DNA adenine methylase (Dam) elicited a cross-protective immune response to different Salmonella serovars. The protection afforded by the Salmonella enterica serovar Typhimurium Dam vaccine was greater than that elicited in mice that survived a virulent infection. S. enterica serovar Typhimurium Dam mutant strains exhibited enhanced sensitivity to mediators of innate immunity such as antimicrobial peptides, bile salts, and hydrogen peroxide. Also, S. enterica serovar Typhimurium Dam(-) vaccines were not immunosuppressive; unlike wild-type vaccines, they failed to induce increased nitric oxide levels and permitted a subsequent robust humoral response to diptheria toxoid antigen in infected mice. Dam mutant strains exhibited a low-grade persistence which, coupled with the nonimmunosuppression and the ectopic protein expression caused by altered levels of Dam, may provide an expanded source of potential antigens in vaccinated hosts.

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Year:  2001        PMID： 11598044      PMCID： PMC100049          DOI： 10.1128/IAI.69.11.6725-6730.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  36 in total

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Journal:  Trends Microbiol       Date:  1996-01       Impact factor: 17.079

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Journal:  Annu Rev Immunol       Date:  1996       Impact factor: 28.527

3.  Correlates of protection induced by live Aro- Salmonella typhimurium vaccines in the murine typhoid model.

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Journal:  Immunology       Date:  1997-04       Impact factor: 7.397

4.  Analysis of nonmethylated GATC sites in the Escherichia coli chromosome and identification of sites that are differentially methylated in response to environmental stimuli.

Authors:  W B Hale; M W van der Woude; D A Low
Journal:  J Bacteriol       Date:  1994-06       Impact factor: 3.490

5.  Protection against oral challenge three months after i.v. immunization of BALB/c mice with live Aro Salmonella typhimurium and Salmonella enteritidis vaccines is serotype (species)-dependent and only partially determined by the main LPS O antigen.

Authors:  C E Hormaeche; P Mastroeni; J A Harrison; R Demarco de Hormaeche; S Svenson; B A Stocker
Journal:  Vaccine       Date:  1996-03       Impact factor: 3.641

6.  Bacterial infection as assessed by in vivo gene expression.

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Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-04       Impact factor: 11.205

7.  Salmonella typhimurium infection in mice induces nitric oxide-mediated immunosuppression through a natural killer cell-dependent pathway.

Authors:  M G Schwacha; J J Meissler; T K Eisenstein
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

8.  Quantitative whole-genome analysis of DNA-protein interactions by in vivo methylase protection in E. coli.

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Journal:  Nat Biotechnol       Date:  1998-06       Impact factor: 54.908

9.  Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

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Authors:  B A Braaten; X Nou; L S Kaltenbach; D A Low
Journal:  Cell       Date:  1994-02-11       Impact factor: 41.582
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  49 in total

1.  DNA adenine methylase is essential for viability and plays a role in the pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae.

Authors:  S M Julio; D M Heithoff; D Provenzano; K E Klose; R L Sinsheimer; D A Low; M J Mahan
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

Review 2.  Roles of DNA adenine methylation in regulating bacterial gene expression and virulence.

Authors:  D A Low; N J Weyand; M J Mahan
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

Review 3.  In vivo expression technology.

Authors:  Michael J Angelichio; Andrew Camilli
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

4.  Structure of the bacteriophage T4 DNA adenine methyltransferase.

Authors:  Zhe Yang; John R Horton; Lan Zhou; Xu Jia Zhang; Aiping Dong; Xing Zhang; Samuel L Schlagman; Valeri Kossykh; Stanley Hattman; Xiaodong Cheng
Journal:  Nat Struct Biol       Date:  2003-08-24

5.  Host response to a dam mutant of Salmonella enterica serovar enteritidis with a temperature-sensitive phenotype.

Authors:  Mónica N Giacomodonato; Sebastián H Sarnacki; Roberto L Caccuri; Daniel O Sordelli; M Cristina Cerquetti
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

6.  The phasevarion: a genetic system controlling coordinated, random switching of expression of multiple genes.

Authors:  Yogitha N Srikhanta; Tina L Maguire; Katryn J Stacey; Sean M Grimmond; Michael P Jennings
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-31       Impact factor: 11.205

7.  Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.

Authors:  John R Horton; Kirsten Liebert; Stanley Hattman; Albert Jeltsch; Xiaodong Cheng
Journal:  Cell       Date:  2005-05-06       Impact factor: 41.582

8.  Altered levels of Salmonella DNA adenine methylase are associated with defects in gene expression, motility, flagellar synthesis, and bile resistance in the pathogenic strain 14028 but not in the laboratory strain LT2.

Authors:  Golnaz Badie; Douglas M Heithoff; Robert L Sinsheimer; Michael J Mahan
Journal:  J Bacteriol       Date:  2006-12-15       Impact factor: 3.490

9.  Altered Ca(2+) regulation of Yop secretion in Yersinia enterocolitica after DNA adenine methyltransferase overproduction is mediated by Clp-dependent degradation of LcrG.

Authors:  Stefan Fälker; M Alexander Schmidt; Gerhard Heusipp
Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

Review 10.  Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.

Authors:  Martin G Marinus; Josep Casadesus
Journal:  FEMS Microbiol Rev       Date:  2009-01-19       Impact factor: 16.408
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