Literature DB >> 11705940

DNA adenine methylase is essential for viability and plays a role in the pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae.

S M Julio1, D M Heithoff, D Provenzano, K E Klose, R L Sinsheimer, D A Low, M J Mahan.   

Abstract

Salmonella strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to different Salmonella species. To generate vaccines against other bacterial pathogens, the dam genes of Yersinia pseudotuberculosis and Vibrio cholerae were disrupted but found to be essential for viability. Overproduction of Dam significantly attenuated the virulence of these two pathogens, leading to, in Yersinia, the ectopic secretion of virulence proteins (Yersinia outer proteins) and a fully protective immune response in vaccinated hosts. Dysregulation of Dam activity may provide a means for the development of vaccines against varied bacterial pathogens.

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Year:  2001        PMID： 11705940      PMCID： PMC98854          DOI： 10.1128/IAI.69.12.7610-7615.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  41 in total

Review 1.  Epigenetic phase variation of the pap operon in Escherichia coli.

Authors:  M van der Woude; B Braaten; D Low
Journal:  Trends Microbiol       Date:  1996-01       Impact factor: 17.079

2.  The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity.

Authors:  S Håkansson; K Schesser; C Persson; E E Galyov; R Rosqvist; F Homblé; H Wolf-Watz
Journal:  EMBO J       Date:  1996-11-01       Impact factor: 11.598

3.  The complete genome sequence of Escherichia coli K-12.

Authors:  F R Blattner; G Plunkett; C A Bloch; N T Perna; V Burland; M Riley; J Collado-Vides; J D Glasner; C K Rode; G F Mayhew; J Gregor; N W Davis; H A Kirkpatrick; M A Goeden; D J Rose; B Mau; Y Shao
Journal:  Science       Date:  1997-09-05       Impact factor: 47.728

4.  The CcrM DNA methyltransferase is widespread in the alpha subdivision of proteobacteria, and its essential functions are conserved in Rhizobium meliloti and Caulobacter crescentus.

Authors:  R Wright; C Stephens; L Shapiro
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

5.  Analysis of nonmethylated GATC sites in the Escherichia coli chromosome and identification of sites that are differentially methylated in response to environmental stimuli.

Authors:  W B Hale; M W van der Woude; D A Low
Journal:  J Bacteriol       Date:  1994-06       Impact factor: 3.490

6.  Bacterial infection as assessed by in vivo gene expression.

Authors:  D M Heithoff; C P Conner; P C Hanna; S M Julio; U Hentschel; M J Mahan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-04       Impact factor: 11.205

7.  YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK.

Authors:  L E Palmer; S Hobbie; J E Galán; J B Bliska
Journal:  Mol Microbiol       Date:  1998-03       Impact factor: 3.501

8.  Differential patterns of acquired virulence genes distinguish Salmonella strains.

Authors:  C P Conner; D M Heithoff; S M Julio; R L Sinsheimer; M J Mahan
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

9.  Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

Authors:  R D Fleischmann; M D Adams; O White; R A Clayton; E F Kirkness; A R Kerlavage; C J Bult; J F Tomb; B A Dougherty; J M Merrick
Journal:  Science       Date:  1995-07-28       Impact factor: 47.728

10.  A cell cycle-regulated bacterial DNA methyltransferase is essential for viability.

Authors:  C Stephens; A Reisenauer; R Wright; L Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-06       Impact factor: 11.205
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  58 in total

Review 1.  Roles of DNA adenine methylation in regulating bacterial gene expression and virulence.

Authors:  D A Low; N J Weyand; M J Mahan
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

2.  Structure of the bacteriophage T4 DNA adenine methyltransferase.

Authors:  Zhe Yang; John R Horton; Lan Zhou; Xu Jia Zhang; Aiping Dong; Xing Zhang; Samuel L Schlagman; Valeri Kossykh; Stanley Hattman; Xiaodong Cheng
Journal:  Nat Struct Biol       Date:  2003-08-24

3.  Exploring the roles of DNA methylation in the metal-reducing bacterium Shewanella oneidensis MR-1.

Authors:  Matthew L Bendall; Khai Luong; Kelly M Wetmore; Matthew Blow; Jonas Korlach; Adam Deutschbauer; Rex R Malmstrom
Journal:  J Bacteriol       Date:  2013-08-30       Impact factor: 3.490

4.  The phasevarion: a genetic system controlling coordinated, random switching of expression of multiple genes.

Authors:  Yogitha N Srikhanta; Tina L Maguire; Katryn J Stacey; Sean M Grimmond; Michael P Jennings
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-31       Impact factor: 11.205

5.  Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.

Authors:  John R Horton; Kirsten Liebert; Stanley Hattman; Albert Jeltsch; Xiaodong Cheng
Journal:  Cell       Date:  2005-05-06       Impact factor: 41.582

6.  A parA homolog selectively influences positioning of the large chromosome origin in Vibrio cholerae.

Authors:  Djenann Saint-Dic; Brian P Frushour; Jason H Kehrl; Lyn Sue Kahng
Journal:  J Bacteriol       Date:  2006-08       Impact factor: 3.490

7.  Altered Ca(2+) regulation of Yop secretion in Yersinia enterocolitica after DNA adenine methyltransferase overproduction is mediated by Clp-dependent degradation of LcrG.

Authors:  Stefan Fälker; M Alexander Schmidt; Gerhard Heusipp
Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

8.  Involvement of the LlaKR2I methylase in expression of the AbiR bacteriophage defense system in Lactococcus lactis subsp. lactis biovar diacetylactis KR2.

Authors:  Julie M Yang; Patricio J Deurraza; Nadya Matvienko; Daniel J O'Sullivan
Journal:  J Bacteriol       Date:  2006-03       Impact factor: 3.490

9.  Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics.

Authors:  Joo-Sung Kim; Jiaqi Li; If H A Barnes; David A Baltzegar; Mohanasundari Pajaniappan; Thomas W Cullen; M Stephen Trent; Christopher M Burns; Stuart A Thompson
Journal:  J Bacteriol       Date:  2008-08-08       Impact factor: 3.490

Review 10.  Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.

Authors:  Martin G Marinus; Josep Casadesus
Journal:  FEMS Microbiol Rev       Date:  2009-01-19       Impact factor: 16.408
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