Literature DB >> 15802471

The phasevarion: a genetic system controlling coordinated, random switching of expression of multiple genes.

Yogitha N Srikhanta1, Tina L Maguire, Katryn J Stacey, Sean M Grimmond, Michael P Jennings.   

Abstract

Several host-adapted bacterial pathogens contain methyltransferases associated with type III restriction-modification (R-M) systems that are subject to reversible, high-frequency on/off switching of expression (phase variation). To investigate the role of phase-variable expression of R-M systems, we made a mutant strain lacking the methyltransferase (mod) associated with a type III R-M system of Haemophilus influenzae and analyzed its phenotype. By microarray analysis, we identified a number of genes that were either up- or down-regulated in the mod mutant strain. This system reports the coordinated random switching of a set of genes in a bacterial pathogen and may represent a widely used mechanism.

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Year:  2005        PMID： 15802471      PMCID： PMC556257          DOI： 10.1073/pnas.0501169102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  HmbR, a hemoglobin-binding outer membrane protein of Neisseria meningitidis, undergoes phase variation.

Authors:  A R Richardson; I Stojiljkovic
Journal:  J Bacteriol       Date:  1999-04       Impact factor: 3.490

2.  Characterization of a CACAG pentanucleotide repeat in Pasteurella haemolytica and its possible role in modulation of a novel type III restriction-modification system.

Authors:  K A Ryan; R Y Lo
Journal:  Nucleic Acids Res       Date:  1999-03-15       Impact factor: 16.971

3.  Microbial genetics. The tinkerer's evolving tool-box.

Authors:  E R Moxon; D S Thaler
Journal:  Nature       Date:  1997-06-12       Impact factor: 49.962

4.  Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection.

Authors:  D Martin; N Cadieux; J Hamel; B R Brodeur
Journal:  J Exp Med       Date:  1997-04-07       Impact factor: 14.307

5.  Adaptation of Haemophilus influenzae to acquired and innate humoral immunity based on phase variation of lipopolysaccharide.

Authors:  J N Weiser; N Pan
Journal:  Mol Microbiol       Date:  1998-11       Impact factor: 3.501

6.  Variable expression of class 1 outer membrane protein in Neisseria meningitidis is caused by variation in the spacing between the -10 and -35 regions of the promoter.

Authors:  A van der Ende; C T Hopman; S Zaat; B B Essink; B Berkhout; J Dankert
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

Review 7.  Biology of DNA restriction.

Authors:  T A Bickle; D H Krüger
Journal:  Microbiol Rev       Date:  1993-06

8.  Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development.

Authors:  S Grimmond; N Van Hateren; P Siggers; R Arkell; R Larder; M B Soares; M de Fatima Bonaldo; L Smith; Z Tymowska-Lalanne; C Wells; A Greenfield
Journal:  Hum Mol Genet       Date:  2000-06-12       Impact factor: 6.150

9.  Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae.

Authors:  Z Ren; H Jin; P W Whitby; D J Morton; T L Stull
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

10.  Brief heat shock treatment induces a long-lasting alteration in the glycolipid receptor binding specificity and growth rate of Haemophilus influenzae.

Authors:  E Hartmann; C Lingwood
Journal:  Infect Immun       Date:  1997-05       Impact factor: 3.441
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  85 in total

1.  Evidence for type III restriction and modification systems in Mycoplasma pulmonis.

Authors:  Kevin Dybvig; Z Cao; C Todd French; Huilan Yu
Journal:  J Bacteriol       Date:  2007-01-05       Impact factor: 3.490

Review 2.  The phage-host arms race: shaping the evolution of microbes.

Authors:  Adi Stern; Rotem Sorek
Journal:  Bioessays       Date:  2011-01       Impact factor: 4.345

3.  Role of Neisseria meningitidis PorA and PorB expression in antimicrobial susceptibility.

Authors:  Ian R Peak; Courtney D Jennings; Freda E-C Jen; Michael P Jennings
Journal:  Antimicrob Agents Chemother       Date:  2013-10-21       Impact factor: 5.191

4.  The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori.

Authors:  Iratxe Estibariz; Annemarie Overmann; Florent Ailloud; Juliane Krebes; Christine Josenhans; Sebastian Suerbaum
Journal:  Nucleic Acids Res       Date:  2019-03-18       Impact factor: 16.971

Review 5.  The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes.

Authors:  Yogitha N Srikhanta; Kate L Fox; Michael P Jennings
Journal:  Nat Rev Microbiol       Date:  2010-02-08       Impact factor: 60.633

Review 6.  Entering the era of bacterial epigenomics with single molecule real time DNA sequencing.

Authors:  Brigid M Davis; Michael C Chao; Matthew K Waldor
Journal:  Curr Opin Microbiol       Date:  2013-02-19       Impact factor: 7.934

7.  Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.

Authors:  John M Atack; Linda E Winter; Joseph A Jurcisek; Lauren O Bakaletz; Stephen J Barenkamp; Michael P Jennings
Journal:  J Infect Dis       Date:  2015-02-23       Impact factor: 5.226

Review 8.  Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.

Authors:  Martin G Marinus; Josep Casadesus
Journal:  FEMS Microbiol Rev       Date:  2009-01-19       Impact factor: 16.408

Review 9.  Conflicts targeting epigenetic systems and their resolution by cell death: novel concepts for methyl-specific and other restriction systems.

Authors:  Ken Ishikawa; Eri Fukuda; Ichizo Kobayashi
Journal:  DNA Res       Date:  2010-11-08       Impact factor: 4.458

10.  A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements.

Authors:  Matteo M E Metruccio; Eva Pigozzi; Davide Roncarati; Francesco Berlanda Scorza; Nathalie Norais; Stuart A Hill; Vincenzo Scarlato; Isabel Delany
Journal:  PLoS Pathog       Date:  2009-12-24       Impact factor: 6.823
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